A Themed Issue in Honor of Professor Robert A. Bonomo—Outstanding Contributions in the Fields of ß-Lactamase Inhibitors

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1176

Special Issue Editors


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Guest Editor
The Warren Alpert Medical School, Providence, RI, USA
Interests: infectious disease; antibiotic administration

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Guest Editor
School of Medicine, Case Western Reserve University, Cleveland, OH, USA
Interests: antimicrobial resistance

Special Issue Information

Dear Colleagues,

This Special Issue will honor Prof. Dr. Robert A. Bonomo for his outstanding contributions in the field of ß-lactamase inhibitors.

Dr. Bonomo is Professor of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics at Case Western Reserve University School of Medicine. He also serves as Chief of the Medical Service at the Louis Stokes Cleveland VA Medical Center, Director of the Cleveland Geriatric Research and Education Clinical Care Center, Vice Chair for Veterans Affairs at the University Hospital Case Medical Center Department of Medicine and Director, CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES). His research interests include the mechanistic basis of resistance to ß-lactam antibiotics and ß-lactamase inhibitors, the molecular epidemiology of multidrug-resistant Gram-negative bacteria, infections in the elderly and the implementation of molecular diagnostics in the clinical care of patients with infectious disease.

Prof. Bonomo has 630+ indexed manuscripts with 63000+ citations (overall, 29953 per year since 2019), an H-index of 116 (564 since 2016) and i-10 index of 564 (445 since 2016), accessed via Google Scholar. Over the course of his career, Bonomo has received more than 70 honors and awards for his research, teaching and clinical care, has more than 65 grants to his name, and has written more than 700 abstracts and 530 peer-reviewed publications. He has educated and advised more than 80 physicians and researchers who have gone on to make contributions to improve the lives of veteran and non-veteran patients here in Cleveland and across the country.

In August 2019, Bonomo was named a Distinguished University Professor, an honorific title that acknowledges the contributions of full-time, tenured faculty with exceptional records of research, scholarship, teaching and service. In 2017, he received VA’s William S. Middleton Award for his contributions to research in the fields of microbiology, epidemiology, diagnosis, prevention and treatment of infectious diseases. In 2016, he became the first non-European to receive the European Society of Clinical Microbiology and Infectious Disease’s Excellence Award for outstanding lifetime contributions to science, education or professional affairs in the field of clinical microbiology and/or infectious disease. He also received a lifetime achievement award from the VA Society of Practitioners of Infectious Diseases (VASPID).

Prof. Dr. Louis B. Rice
Prof. Dr. Federico Perez
Guest Editors

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Keywords

  • antibiotic resistance
  • beta-lactamases
  • multidrug-resistant bacteria

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Published Papers (1 paper)

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Research

10 pages, 263 KiB  
Article
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Diarrhoeal Faeces from 0 to 5-Year-Old Children Attending Public Hospitals in Franceville, Gabon
by Anicet-Clotaire Dikoumba, Pierre Philippe Mbehang Nguema, Leresche Even Doneilly Oyaba Yinda, Romeo Wenceslas Lendamba, Jean Constan Obague Mbeang, Guy Roger Ndong Atome, Christophe Roland Zinga Koumba, Sylvain Godreuil and Richard Onanga
Antibiotics 2024, 13(11), 1059; https://doi.org/10.3390/antibiotics13111059 - 7 Nov 2024
Viewed by 818
Abstract
Background: In Gabon, studies on the characterization of extended-spectrum beta-lactamase-producing Escherichia coli in young children with diarrhoea are almost nonexistent. The objective was to evaluate the prevalence of antibiotic resistance to extended-spectrum beta-lactamase-producing Escherichia coli in children at public hospitals in Franceville, Gabon. [...] Read more.
Background: In Gabon, studies on the characterization of extended-spectrum beta-lactamase-producing Escherichia coli in young children with diarrhoea are almost nonexistent. The objective was to evaluate the prevalence of antibiotic resistance to extended-spectrum beta-lactamase-producing Escherichia coli in children at public hospitals in Franceville, Gabon. Methods: Seventy diarrhoea faecal samples were collected from children aged 0–5 years. The culture and isolation of colonies were carried out on MacConkey agar. The colonies were identified using VITEK 2. The determination of the extended-spectrum beta-lactamase’s profiles was accomplished using the double disk method. The identification of phylogroups and pathotypes was performed by PCR. Identification of the ESBL genes was performed by sequencing. Results: A total of 26 strains of Escherichia coli (33.0%) were identified from 78 bacterial isolates. Twenty (77.0%) Escherichia coli strains carried extended-spectrum beta-lactamases blaCTX-M-15 and 5.0% carried blaSHV-12 subtypes. Phylogroup D (62.0%) was predominant, followed by B1 (12.0%), B2 (8.0%) and E (4.0%). The bacterial pathogens causing diarrhoea were enterohemorrhagic E. coli (12.0%), typical enteropathogenic Escherichia coli (8.0%), atypical enteropathogenic Escherichia coli (4.0%), Enteroaggregative Escherichia coli (4.0%) and enteroinvasive E. coli (4.0%). Conclusions: This study showed a high prevalence of extended-spectrum beta-lactamase, Escherichia coli of phylogroup D and pathotype enterohemorrhagic Escherichia coli in children under 5 years old in public hospitals in Franceville, most probably due to the misuse or inappropriate consumption of beta-lactams. Full article
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