Exploring Antimicrobial Resistance in Foodborne Pathogens: Microbiological Perspectives

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3470

Special Issue Editor


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Guest Editor
Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
Interests: foodborne pathogens; stress tolerance; antibiotic resistance

Special Issue Information

Dear Colleagues,

Studying antibiotic resistance in foodborne pathogens is imperative in order to address this growing public health concern. Major foodborne pathogens are mostly of animal origin and develop antibiotic resistance in their hosts primarily due to the use of antibiotics in agriculture. Antibiotic-resistant foodborne pathogens can persist in the food supply and be transmitted to humans via foodborne routes. Since foodborne pathogens cause billions of infection cases worldwide each year, which are increasingly associated with antibiotic resistance, it is crucial to understand the mechanisms and factors contributing to the development and transmission of antibiotic resistance to develop effective intervention strategies. In this Special Issue, we invite research articles related to, but not limited to, the areas below:

  • Mechanisms of antibiotic resistance development and transmission in foodborne pathogens.
  • The impact of antibiotic use in agriculture on antibiotic resistance in foodborne pathogens.
  • The prevalence of antibiotic-resistant foodborne pathogens in food products and environments.
  • Alternative approaches to the control of antibiotic resistance in foodborne pathogens.

Dr. Byeonghwa Jeon
Guest Editor

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Keywords

  • foodborne pathogens
  • prevalence of antibiotic resistance
  • resistance development
  • resistance transmission
  • agricultural antibiotics
  • antibiotic alternatives

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Published Papers (2 papers)

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13 pages, 2540 KiB  
Article
Antimicrobial and Phylogenomic Characterization of Bacillus cereus Group Strains Isolated from Different Food Sources in Italy
by Donatella Farina, Angelica Bianco, Viviana Manzulli, Stefano Castellana, Antonio Parisi, Marta Caruso, Rosa Fraccalvieri, Luigina Serrecchia, Valeria Rondinone, Lorenzo Pace, Antonio Fasanella, Valerio Vetritto, Laura Maria Difato, Dora Cipolletta, Michela Iatarola and Domenico Galante
Antibiotics 2024, 13(9), 898; https://doi.org/10.3390/antibiotics13090898 - 20 Sep 2024
Viewed by 1268
Abstract
Background: Bacillus cereus is a widespread environmental Gram-positive bacterium which is especially common in soil and dust. It produces two types of toxins that cause vomiting and diarrhea. At present, foodborne outbreaks due to Bacillus cereus group bacteria (especially Bacillus cereus sensu [...] Read more.
Background: Bacillus cereus is a widespread environmental Gram-positive bacterium which is especially common in soil and dust. It produces two types of toxins that cause vomiting and diarrhea. At present, foodborne outbreaks due to Bacillus cereus group bacteria (especially Bacillus cereus sensu stricto) are rising, representing a serious problem in the agri-food supply chain. Methods: In this work, we analyzed 118 strains belonging to the Bacillus cereus group, isolated from several food sources, for which in vitro and in silico antibiotic resistance assessments were performed. Results: Many strains showed intermediate susceptibility to clindamycin, erythromycin, and tetracycline, suggesting an evolving acquisition of resistance against these antibiotics. Moreover, one strain showed intermediate resistance to meropenem, an antibiotic currently used to treat infections caused by Bacillus cereus. In addition to the phenotypic antimicrobial resistance profile, all strains were screened for the presence/absence of antimicrobial genes via whole-genome sequencing. There was inconsistency between the in vitro and in silico analyses, such as in the case of vancomycin, for which different isolates harbored resistance genes but, phenotypically, the same strains were sensitive. Conclusions: This would suggest that antibiotic resistance is a complex phenomenon due to a variety of genetic, epigenetic, and biochemical mechanisms. Full article
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13 pages, 1435 KiB  
Article
Prevalence and Phage-Based Biocontrol of Methicillin-Resistant Staphylococcus aureus Isolated from Raw Milk of Cows with Subclinical Mastitis in Vietnam
by Hoang Minh Son and Hoang Minh Duc
Antibiotics 2024, 13(7), 638; https://doi.org/10.3390/antibiotics13070638 - 10 Jul 2024
Cited by 1 | Viewed by 1770
Abstract
S. aureus, particularly methicillin-resistant S. aureus, has been recognized as a main cause of bovine mastitis and food poisoning. This study investigated the prevalence, antibiotic resistance, and phage-based biocontrol of S. aureus and methicillin-resistant S. aureus isolated from raw milk of [...] Read more.
S. aureus, particularly methicillin-resistant S. aureus, has been recognized as a main cause of bovine mastitis and food poisoning. This study investigated the prevalence, antibiotic resistance, and phage-based biocontrol of S. aureus and methicillin-resistant S. aureus isolated from raw milk of cows with subclinical mastitis. The results showed that the prevalence of S. aureus and methicillin-resistant S. aureus was 12% (48/400) and 1.5% (6/400), respectively. The S. aureus isolates were highly resistant to penicillin (72.92%), erythromycin (43.75%), and tetracycline (39.58%). Out of 48 S. aureus isolates, 6 were identified as methicillin-resistant strains. Among them, one isolate was found to harbor the sea gene. A total of 5 phages were recovered from 50 pork and 50 chicken meat samples, 1 from pork and 4 from chicken meat samples. Phage PSA2 capable of lysing all 6 methicillin-resistant isolates was selected for characterization. The use of phage PSA2 completely inactivated methicillin-resistant S. aureus SA33 in raw milk at both 24 °C and 4 °C, indicating its potential as a promising antibacterial agent in controlling methicillin-resistant S. aureus in raw milk and treating bovine mastitis. Full article
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