Antibacterial, Antifungal and Anti-infective Activity of Natural Products

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 3023

Special Issue Editor


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Guest Editor
Institute of Bioproduct Development (IBD), Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru 81310, Malaysia
Interests: natural bioactive compounds; anti-infectives; bioprocess Industry; anti-inflammatory natural compounds; probiotics and prebiotics; mushrooms; biorefinery

Special Issue Information

Dear Colleagues,

Plants are considered to be the oldest known biofactories for the production of bioactive molecules of many pharmaceutical activities for the treatment of chronic and non-chronic diseases. Therefore, for centuries, plant extracts were essential components of folk and traditional medicine. Antimicrobial and anti-inflammatory properties were among the most needed functional properties of plant extracts. They played essential roles as natural healers for the treatment of different diseases. However, with the increased awareness of the potential side effects of microbial-based antibiotics and the development of many resistance microbial strains against many known antibiotics, researchers have started to rethink about the importance of revisiting plant-based bioactive molecules as alternative therapy. Therefore, in recent years, many researchers have focused on going “back to a plant-based medicine approach” for the discovery and production of plant extracts of antimicrobial and anti-inflammatory properties. These molecules are nowadays considered to be high-potential biotherapeutic alternatives to reduce the side effects of the currently used microbial-derived or synthetic molecules. Therefore, the main aim of this Special Issue is to publish up-to-date research related to the recent development of the discovery, isolation, identification, and molecular characterization of plant bioactive compounds of antimicrobial and anti-inflammatory activities. In addition, we also welcome research related to antimicrobial, in vitro and in vivo testing, and cytotoxicity assessment of these compounds. We welcome manuscripts in the form of reviews or scientific research articles.

Prof. Dr. Hesham A. El Enshasy
Guest Editor

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Keywords

  • plant antimicrobials
  • bioactive molecules
  • plant anti-inflammatory
  • in vivo and in vitro testing
  • extraction and purification
  • molecular characterization
  • biological activity
  • biorefinery of bioactive plant extracts
  • safety and regulation of plant antimicrobials

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Published Papers (1 paper)

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Research

17 pages, 4299 KiB  
Article
Phyto-Inhibitory and Antimicrobial Activity of Brown Propolis from Romania
by Mihaela Laura Vică, Mirel Glevitzky, Ramona Cristina Heghedűş-Mîndru, Gabriela-Alina Dumitrel, Gabriel Heghedűş-Mîndru, Maria Popa, Doriana Maria Faur, Ștefana Bâlici and Cosmin Adrian Teodoru
Antibiotics 2023, 12(6), 1015; https://doi.org/10.3390/antibiotics12061015 - 5 Jun 2023
Cited by 4 | Viewed by 2392
Abstract
The objective of this paper was to study the phyto-inhibitory and antimicrobial activity of brown propolis collected from the counties of four regions in Romania. The main physico-chemical and functional properties of 16 samples of propolis from different landforms of geographical regions were [...] Read more.
The objective of this paper was to study the phyto-inhibitory and antimicrobial activity of brown propolis collected from the counties of four regions in Romania. The main physico-chemical and functional properties of 16 samples of propolis from different landforms of geographical regions were determined. Their antimicrobial activities were established against 5 bacterial strains (Pseudomonas fluorescens, Bacillus subtilis, Bacillus cereus, Escherichia coli, and Proteus mirabilis) and 5 fungal strains (Alternaria alternata, Cladosporium cladosporioides, Fusarium oxysporum, Mucor racemosus, and Aspergillus niger). Simultaneously, the phyto-inhibitory effect of propolis samples on different cereals was highlighted: hexaploid bread wheat (Triticum aestivum), maize (Zea mays L.), oats (Avena sativa L.), and barley (Hordeum vulgare L.). Correlations between the antioxidant activity and total flavonoid and phenol content of the propolis samples were identified, respectively, and the statistical analysis highlighted that the diameter of the inhibition zone was influenced by the strain type (bacterial and fungal) and the geographical regions of propolis. Principal component analysis (PCA) indicated that out of seven principal components, only two exhibited > 0.5. Pearson’s correlation coefficient showed a low and moderate positive linear relationship between the diameter of the inhibition zone and the flavonoid and phenol concentration of the propolis samples. Full article
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