Special Issue "Chemical Tools for Antibiotics Research"
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: 30 April 2019
Dr. Gerd Wagner
Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK
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Interests: anti-infective drug discovery; enzyme inhibitors; chemical tools; bacterial glycans; glycosyltransferases; glycosylation; assays; bacterial proteomics; antimicrobial resistance; virulence mechanisms
Antimicrobial resistance is a growing threat to human and animal health. Bacterial strains that are resistant to antibiotics of last resort, including Klebsiella pneumoniae and Neisseria gonorrhoea, are emerging at an alarming rate. The discovery of new antibiotics is therefore an urgent scientific and technological challenge.
This Special Issue showcases recent examples of chemical tools to address this challenge.
Chemical tools such as small molecule inhibitors and probes occupy a unique place in the arsenal of techniques to study biological systems. They can be used for the mechanistic and structural characterisation of individual proteins, but also for the proteome-wide interrogation of an entire organism. Chemical tools allow reversible, dose- and time-dependent interventions in a manner that few other techniques can, but also permanent labelling experiments in intact cells. They are powerful tools for target identification and validation studies, and can themselves serve as chemical starting points for antibiotics discovery.
Perhaps one of the most exciting features of chemical tools is their applicability across species boundaries, with wild-type bacteria and clinical strains. This Special Issue brings together recent case studies of chemical tools in antibiotics research with different pathogens—not least in the hope that it will promote the availability of these tools to a wide audience across the microbiology, infectious disease and drug discovery communities.
Dr. Gerd Wagner
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Chemical tool
- enzyme inhibitor
- small molecule
- molecular probe
- antimicrobial resistance