Novel Antimicrobials for ESKAPE Pathogens: From Research to Treatment
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 533
Special Issue Editors
Interests: medicinal chemistry; antimicrobial resistance; antimicrobial agents; Mycobacterium tuberculosis; autophagy; iron based antimicrobial agents; asthama and COPD; anticancer agents
Interests: drug discovery; medicinal chemistry; antimicrobial resistance
Special Issue Information
Dear Colleagues,
Antimicrobial resistance (AMR) poses one of the most serious threats to global public health, a challenge further exacerbated by the declining number of truly novel antimicrobial agents in the pharmaceutical pipeline. Over the past decades, AMR has increased at an alarming rate, becoming a critical worldwide issue for modern healthcare systems. This crisis has led to substantially higher rates of morbidity and mortality in both community and hospital settings. In the United States alone, more than 2 million infections and approximately 23,000 deaths annually are attributed to antibiotic-resistant Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, collectively known as the ESKAPE pathogens. These microorganisms are responsible for the majority of hospital-acquired infections and are particularly notorious for their ability to evade the effects of existing antibiotics through diverse resistance mechanisms, including drug inactivation, target modification, efflux, and biofilm formation.
This Special Issue aims to highlight recent advances and emerging strategies to combat ESKAPE pathogens and address the urgent global need for next-generation antimicrobial therapies, including metal-based antimicrobials, anti-biofilm strategies, host-directed therapies, antimicrobial peptides, nanomaterials, and combination treatments. By focusing on innovative approaches that go beyond conventional antibiotics, this Special Issue seeks to provide a coherent and impactful resource for the research community.
Dr. Nalin Abeydeera
Dr. Bishnu Pant
Dr. Sara Scutera
Guest Editors
Manuscript Submission Information
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Keywords
- antimicrobial resistance
- ESKAPE pathogens
- novel antibiotics
- metal-based antimicrobials
- antibiofilm agents
- drug discovery
- nanomaterials
- host-directed therapy
- combination therapy
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