Antimicrobial Resistance of Staphylococcus spp. in Animals: A One Health Perspective

Dear Colleagues,

Staphylococci are commensal colonizers of skin and mucosal surfaces in humans and warm-blooded animals and are also considered opportunistic pathogens causing a wide range of infections. S. aureus exhibits high levels of pathogenicity and antimicrobial resistance (AMR), whereas non-aureus staphylococci (NAS) have been overlooked due to their relatively low virulence and AMR., contributing to the dissemination of AMR within the Staphylococcus spp. Given that NAS can serve as reservoirs of antimicrobial resistance genes (ARGs), comprehensive studies encompassing both SA and NAS are needed to understand ARG transfer among staphylococci.

This Special Issue aims to bring together the latest research on the AMR of staphylococci in animals, focusing on the prevalence and AMR profiles of staphylococcal isolates recovered from animal sectors. Additionally, studies investigating staphylococci isolated from humans and the environment associated with animals are also encouraged to provide a multisectoral perspective. By analyzing large-scale datasets—including (meta)genome, mobilome, and resistome—this issue seeks to uncover not only the mechanism of AMR gene transfer among staphylococci but also the spread of ARGs and antimicrobial-resistant staphylococci across different sectors using the One Health approach.

• Prevalence and AMR profiles of Staphylococcus spp. in animals.
• One Health approaches to understand the epidemiology and transmission dynamics of staphylococcal isolates across animal, human, and environmental sectors.
• Genetic factors and molecular mechanisms associated with AMR in staphylococci.
• Omics-based studies integrating metadata, such as (meta)genome, mobilome, and resistome.
• Innovative strategies for controlling the spread of antimicrobial-resistant staphylococci and ARG transfer.

Through this Special Issue, we aim to provide a comprehensive overview of the factors contributing to the persistence and spread of antimicrobial-resistant staphylococci in animals. By fostering interdisciplinary research, we hope to emphasize the importance of surveillance, monitoring, and preventive strategies to address this growing challenge for One Health.

Dr. Gi Yong Lee
Guest Editor

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