Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Antimicrobial Treatment and Management of Central Nervous System Infections
share announcement

Antimicrobial Treatment and Management of Central Nervous System Infections

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1265

Special Issue Editors

Dr. Liana Signorini

E-Mail Website
Guest Editor
Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy
Interests: antibiotic resistance; antimicrobial stewardship; ICU infections; endocarditis; CNS infections
Dr. Angelo Pan

E-Mail Website
Guest Editor
UOC Malattie Infettive e Tropicali, ASST Cremona, 26100 Cremona, Italy
Interests: antibiotic resistance; antimicrobial stewardship; infection control; CNS infections

Special Issue Information

Dear Colleagues,

The central nervous system (CNS) might be considered a sanctuary for infections. Transport of fluid and solutes is tightly controlled within the CNS, as the entry of drugs into the cerebrospinal fluid (CSF) is governed by molecular size, lipophilicity, plasma protein binding and their affinity to transport systems at the blood–brain barrier (BBB). For these reasons, CNS infections, especially in hospital settings, are a therapeutic challenge for Specialists of Infectious Diseases (IDs).

In the literature, only a few papers are available regarding therapeutic regimens for hospital-acquired (HA) CNS infections, especially in terms of requiring antibiotics combinations or therapy duration. In the absence of updated guidelines, there is little experience in the use of novel antibiotics in difficult-to-treat pathogens which are increasingly responsible for nosocomial infections in Neurosurgery Departments.

This Special Issue seeks manuscript submissions that deepen our understanding of the treatment and management of CNS infections and broaden our knowledge in this challenging field, in particular regarding HA Infections. Submissions regarding pharmacokinetic studies of novel antibiotics in HA CNS infections are especially encouraged.

Acknowledgment: Silvia Lorenzotti and Barbara Saccani will be participating in this Special Issue as "Special collaborators". We thank them for their contributions.

Dr. Liana Signorini
Dr. Angelo Pan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • central nervous system
  • CNS
  • hospital-acquired infection
  • nosocomial
  • neurosurgery
  • external ventricular drainage
  • EVD
  • post-neurosurgical meningitis
  • bacterial colonization

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Other

11 pages, 1489 KiB  
Case Report
Cerebral Infectious Opportunistic Lesions in a Patient with Acute Myeloid Leukaemia: The Challenge of Diagnosis and Clinical Management
by Gabriele Cavazza, Cristina Motto, Caroline Regna-Gladin, Giovanna Travi, Elisa Di Gennaro, Francesco Peracchi, Bianca Monti, Nicolò Corti, Rosa Greco, Periana Minga, Marta Riva, Sara Rimoldi, Marta Vecchi, Carlotta Rogati, Davide Motta, Annamaria Pazzi, Chiara Vismara, Laura Bandiera, Fulvio Crippa, Valentina Mancini, Maria Sessa, Chiara Oltolini, Roberto Cairoli and Massimo Puotiadd Show full author list remove Hide full author list
Antibiotics 2024, 13(5), 387; https://doi.org/10.3390/antibiotics13050387 - 24 Apr 2024
Viewed by 255
Abstract
Central nervous system (CNS) lesions, especially invasive fungal diseases (IFDs), in immunocompromised patients pose a great challenge in diagnosis and treatment. We report the case of a 48-year-old man with acute myeloid leukaemia and probable pulmonary aspergillosis, who developed hyposthenia of the left [...] Read more.
Central nervous system (CNS) lesions, especially invasive fungal diseases (IFDs), in immunocompromised patients pose a great challenge in diagnosis and treatment. We report the case of a 48-year-old man with acute myeloid leukaemia and probable pulmonary aspergillosis, who developed hyposthenia of the left upper limb, after achieving leukaemia remission and while on voriconazole. Magnetic resonance imaging (MRI) showed oedematous CNS lesions with a haemorrhagic component in the right hemisphere with lepto-meningitis. After 2 weeks of antibiotics and amphotericin-B, brain biopsy revealed chronic inflammation with abscess and necrosis, while cultures were negative. Clinical recovery was attained, he was discharged on isavuconazole and allogeneic transplant was postponed, introducing azacitidine as a maintenance therapy. After initial improvement, MRI worsened; brain biopsy was repeated, showing similar histology; and 16S metagenomics sequencing analysis was positive (Veilonella, Pseudomonas). Despite 1 month of meropenem, MRI did not improve. The computer tomography and PET scan excluded extra-cranial infectious–inflammatory sites, and auto-immune genesis (sarcoidosis, histiocytosis, CNS vasculitis) was deemed unlikely due to the histological findings and unilateral lesions. We hypothesised possible IFD with peri-lesion inflammation and methyl-prednisolone was successfully introduced. Steroid tapering is ongoing and isavuconazole discontinuation is planned with close follow-up. In conclusion, the management of CNS complications in immunocompromised patients needs an interdisciplinary approach. Full article
(This article belongs to the Special Issue Antimicrobial Treatment and Management of Central Nervous System Infections)
►▼ Show Figures

Figure 1

7 pages, 220 KiB  
Case Report
Meropenem–Vaborbactam for the Treatment of Post-Neurosurgical Meningitis Caused by KPC Producer Klebsiella Pneumoniae: A Case Report and Review of the Literature
by Leonardo Francesco Rezzonico, Francesco Peracchi, Marta Vecchi, Gabriele Bassi, Marco Merli, Nicholas Brian Bana, Giovanna Travi, Fulvio Crippa and Massimo Puoti
Antibiotics 2024, 13(4), 331; https://doi.org/10.3390/antibiotics13040331 - 05 Apr 2024
Viewed by 751
Abstract
Meningitis and ventriculitis, due to carbapenem-resistant Enterobacterales, are frequently associated with significant morbidity and mortality. In the case of multi-drug-resistant pathogens, it is necessary to consider the limited susceptibility profile as well as the penetration of the antimicrobials into the brain. Limited [...] Read more.
Meningitis and ventriculitis, due to carbapenem-resistant Enterobacterales, are frequently associated with significant morbidity and mortality. In the case of multi-drug-resistant pathogens, it is necessary to consider the limited susceptibility profile as well as the penetration of the antimicrobials into the brain. Limited data are available regarding the treatment of central nervous system infections caused by carbapenem-resistant Enterobacterales. We report a study of a patient treated with meropenem–vaborbactam in the case of post-neurosurgical meningitis due to carbapenemase-producing Klebsiella pneumoniae (CPKP). Full article
(This article belongs to the Special Issue Antimicrobial Treatment and Management of Central Nervous System Infections)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop