Companion Animal Genetics

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 6271

Special Issue Editors


E-Mail Website
Guest Editor
1. VetAgro Sup (Lyon National School of Veterinary Medicine), Lyon, France
2. INMG (Institut NeuroMyogène), CNRS UMR 5310—INSERM U1217—UCBL1-Université de Lyon, Lyon, France
Interests: feline genetics; animal genetics; animal breeding; animal models
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Ecole Nationale Vétérinaire d’Alfort (Alfort National School of Veterinary Medicine), Maisons-Alfort, France
2. U955–IMRB, Team 10–Biology of the Neuromuscular System, Inserm, UPEC, EFS, EnvA, Maisons-Alfort, France
Interests: canine genetics; animal genetics; animal breeding; animal models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The small number of foundation breeding stocks, strict selection of males and females at each generation, popular sire effect and effects of linebreeding and inbreeding have led not only to the development of homogenous domestic breeds, but also to an increasing number of animals affected by inherited diseases, especially recessive diseases.

In the last 20 years, the study of dogs and cats has benefited from the progress of genomic tools (SNP arrays, whole-genome association studies, exome and whole-genome sequencing) and resources (genome sequences). Meanwhile, genomes from other companion animals (e.g., rabbits, rodents, ferrets, birds) have also been sequenced, paving the way for successful gene and mutation characterization in these species. Mutation identifications allow the development of DNA tests. These tests are used by breeders and veterinarians to select breeding stocks and improve animal health and welfare.

For this Special Issue, original manuscripts covering all aspects of morbid or interest inherited traits in companion animal (e.g., dogs, cats, ferrets, rabbits, guinea pigs, birds, horses), are invited, including phenotypic and genetic description (inheritance pattern), identification of new genes and mutations, genotype–phenotype correlation and in-depth characterization of known mutations. Morbid traits will be preferred but interest traits are welcome, including morphological traits, coat (feather) color and texture.

We invite original research papers on companion animal genetics, including molecular characterization of morbid or interest traits, association or linkage studies, whole-genome or exome sequencing assays and genotype–phenotype correlation studies that address the genetic or biological mechanisms underlying Mendelian or complex (quantitative) traits, to give insight into the etiology and impact of genetic disorder or interest traits so as to explore opportunities for health and welfare improvement in companion animals.

Prof. Marie Abitbol
Dr. Lucie Chevallier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Canine genetics
  • Feline genetics
  • Companion animal genetics
  • Inherited diseases
  • Interest traits
  • Coat color genetics
  • Molecular genetics
  • Selection
  • Companion animal breeding

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 4537 KiB  
Article
Insight into the Candidate Genes and Enriched Pathways Associated with Height, Length, Length to Height Ratio and Body-Weight of Korean Indigenous Breed, Jindo Dog Using Gene Set Enrichment-Based GWAS Analysis
by Sunirmal Sheet, Jong-Seok Kim, Min-Jeong Ko, Na-Yeon Kim, Young-Jo Lim, Mi-Rim Park, Seung-Jin Lee, Jeong-Min Kim, Seok-Il Oh and Bong-Hwan Choi
Animals 2021, 11(11), 3136; https://doi.org/10.3390/ani11113136 - 2 Nov 2021
Cited by 4 | Viewed by 5273
Abstract
As a companion and hunting dog, height, length, length to height ratio (LHR) and body-weight are the vital economic traits for Jindo dog. Human selection and targeted breeding have produced an extraordinary diversity in these traits. Therefore, the identification of causative markers, genes [...] Read more.
As a companion and hunting dog, height, length, length to height ratio (LHR) and body-weight are the vital economic traits for Jindo dog. Human selection and targeted breeding have produced an extraordinary diversity in these traits. Therefore, the identification of causative markers, genes and pathways that help us to understand the genetic basis of this variability is essential for their selection purposes. Here, we performed a genome-wide association study (GWAS) combined with enrichment analysis on 757 dogs using 118,879 SNPs. The genomic heritability (h2) was 0.33 for height and 0.28 for weight trait in Jindo. At p-value < 5 × 10−5, ten, six, thirteen and eleven SNPs on different chromosomes were significantly associated with height, length, LHR and body-weight traits, respectively. Based on our results, HHIP, LCORL and NCAPG for height, IGFI and FGFR3 for length, DLK1 and EFEMP1 for LHR and PTPN2, IGFI and RASAL2 for weight can be the potential candidate genes because of the significant SNPs located in their intronic or upstream regions. The gene-set enrichment analysis highlighted here nine and seven overlapping significant (p < 0.05) gene ontology (GO) terms and pathways among traits. Interestingly, the highlighted pathways were related to hormone synthesis, secretion and signalling were generally involved in the metabolism, growth and development process. Our data provide an insight into the significant genes and pathways if verified further, which will have a significant effect on the breeding of the Jindo dog’s population. Full article
(This article belongs to the Special Issue Companion Animal Genetics)
Show Figures

Figure 1

Back to TopTop