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5.2
2.7
Journals
Animals
Special Issues
Molecular Pathways of Fish Immune Responses
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Molecular Pathways of Fish Immune Responses

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Aquatic Animals".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 394

Special Issue Editors

Dr. Yinnan Mu

E-Mail Website
Guest Editor
College of Marine Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 350002, China
Interests: fish immunology; fish disease and its control
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Xiuzhen Sheng

E-Mail Website
Guest Editor
Laboratory of Pathology and Immunology of Aquatic Animals, Ocean University of China, Qingdao 266003, China
Interests: fish immunity; viruses; virus-host interactions; cellular receptor; viral attachment proteins; lymphocystis disease virus; FV3; mucosal immunity; IgM; polymeric Ig receptor (pIgR); mucin; mucous cells; microfold cells; diagnostic technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aquaculture serves as a significant source of high-quality protein for human consumption, with fish farming constituting a vital component of this industry. During the fish breeding process, the frequent occurrence of bacterial, viral, and parasitic diseases leads to substantial losses. A comprehensive understanding of the molecular mechanisms of immune responses in fish is essential for enhancing disease management, which is of critical importance to the aquaculture industry. This Special Issue is dedicated to the publication of original research articles and comprehensive reviews focusing on the molecular immune responses of fish. Topics of interest include the innate immune molecules, adaptive immune molecules, and signal transduction mechanisms involved in the immune responses of fish.

Dr. Yinnan Mu
Prof. Dr. Xiuzhen Sheng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aquaculture
  • fish
  • disease
  • immune
  • molecular mechanisms

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Published Papers (1 paper)

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Research

17 pages, 7718 KB  
Article
Identification and Functional Characterization of a Novel Long Non-Coding RNA NLRP14-OT in Turbot (Scophthalmus maximus) Immune Response Against Vibrio anguillarum Infection
by Beibei Wang, Yiying Liu, Yang Li, Xiaoli Liu, Ning Yang and Chao Li
Animals 2026, 16(10), 1443; https://doi.org/10.3390/ani16101443 - 8 May 2026
Viewed by 143
Abstract
As an important member of non-coding RNAs, lncRNAs play a significant role in various biological processes, including regulating the immune response after bacterial infection. In this study, we identified a novel lncRNA (NLRP14-OT) in turbot (Scophthalmus maximus). As a [...] Read more.
As an important member of non-coding RNAs, lncRNAs play a significant role in various biological processes, including regulating the immune response after bacterial infection. In this study, we identified a novel lncRNA (NLRP14-OT) in turbot (Scophthalmus maximus). As a result, NLRP14-OT was more than 2234 bp in length and was detectable in the liver, spleen, head kidney, intestine, skin, gill, muscles, blood, and brain, with the highest expression levels in the blood, followed by the spleen. To better understand the biological significance of lncRNAs in the immune system, this study performed qPCR on mucosal tissues (intestine, skin, and gill) at 0, 2, 6, 12, 24, and 48 h after Vibrio anguillarum (V. anguillarum) infection. Following infection with V. anguillarum, the expression of NLRP14-OT was significantly upregulated in the skin but significantly downregulated in the gill. Given that lncRNAs can regulate target genes through different mechanisms depending on their subcellular localization, we explored the localization of NLRP14-OT. Both RNA nucleoplasmic isolation and FISH experiments showed that NLRP14-OT was predominantly localized in the nucleus. GO and KEGG analyses indicated that NLRP14-OT was involved in several pathways related to the immune response such as the Tight junction, the Ras signaling pathway, and the Rap1 signaling pathway. Moreover, overexpression of NLRP14-OT in SMK cells significantly upregulated all tested immune genes, and this effect was further enhanced upon LPS stimulation at 6 h, suggesting a potential regulatory role for NLRP14-OT in the immune system. Meanwhile, it was found that overexpression of NLRP14-OT could activate the promoter activity of NLRP14 gene and inhibit the NF-κB activity. The above results enrich the information of lncRNAs in teleost and provide a resource base for further research on the immune function of lncRNAs. Full article
(This article belongs to the Special Issue Molecular Pathways of Fish Immune Responses)
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