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Animals
Special Issues
Developments in Therapeutic Drugs for Pain Management in Animals
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Developments in Therapeutic Drugs for Pain Management in Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 1 June 2025 | Viewed by 934

Special Issue Editors

Dr. Dominique Van der Saag

E-Mail Website
Guest Editor
Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camperdown, NSW 2050, Australia
Interests: animal welfare; animal pain; pain management in livestock; pain measurement; pharmacology of pain management
Special Issues, Collections and Topics in MDPI journals
Dr. Sabrina Lomax

E-Mail Website
Guest Editor
Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camperdown, NSW 2050, Australia
Interests: animal welfare; animal pain; pain management in livestock; pain measurement; pharmacology of pain management
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pain is characterised as a negative affect within the Five Domains model of animal welfare. Effectively treating pain continues to be a challenge we face in ensuring positive welfare for animals under our care. We are challenged by the practical constraints of administering animal treatments, species variability in response to therapeutic treatment, safety considerations and limitations to therapeutic efficacy, including duration of the drug effect.

We are pleased to invite you to submit to this Special Issue on the developments in therapeutic drugs for pain management in animals. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: novel therapeutics for the treatment of pain in animals; novel applications for existing therapeutics for the treatment of pain in animals; new species-specific information on the pharmacology, efficacy and safety of novel and existing therapeutics for the treatment of pain in animals; and novel drug delivery systems.

We look forward to receiving your contributions.

Dr. Dominique Van der Saag
Dr. Sabrina Lomax
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • analgesia
  • animal welfare
  • drug delivery
  • pharmacology
  • pain management
  • pain therapeutics

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Published Papers (1 paper)

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Research

17 pages, 986 KiB  
Article
The Effect of Lidocaine Splash Block Followed by Suspensory Ligament Massage in Female Dogs Undergoing Ovariohysterectomy: A Prospective Study
by Eugenia Flouraki, Epameinondas Loukopoulos, Dimitrios Gougoulis, Ioannis Savvas, Chrysoula Margeti, Konstantina Karagianni and Vassiliki Tsioli
Animals 2024, 14(23), 3522; https://doi.org/10.3390/ani14233522 - 5 Dec 2024
Viewed by 404
Abstract
The administration of lidocaine as part of multimodal analgesia in dogs undergoing ovariohysterectomies demonstrates variable analgesic efficacy. The aim of this prospective, double–blinded clinical study was to evaluate the effectiveness of lidocaine 2% irrigation on the ovarian suspensory ligament, followed by localised massage, [...] Read more.
The administration of lidocaine as part of multimodal analgesia in dogs undergoing ovariohysterectomies demonstrates variable analgesic efficacy. The aim of this prospective, double–blinded clinical study was to evaluate the effectiveness of lidocaine 2% irrigation on the ovarian suspensory ligament, followed by localised massage, in achieving sufficient intraoperative analgesia. Thirty-eight female dogs were randomly divided to two groups and received either a splash block of 0.5 ml lidocaine 2% on each ovarian suspensory ligament (GL) or an equal volume of saline (GNS). All dogs were premedicated with dexmedetomidine (5 μg·kg−1) and buprenorphine (20 μg·kg−1) intramuscularly and meloxicam (0.2 mg·kg−1) subcutaneously. Anaesthesia was induced with propofol and maintained with isoflurane. The surgical procedure was initiated after an adequate depth of anaesthesia was achieved. Heart rate (HR), respiratory rate (fR) and mean arterial pressure (MAP) were continuously monitored. Fentanyl (2 μg·kg−1) was administered as rescue analgesia in case of a 30% increase in HR, fR, or MAP, compared to their values before manipulation of the ovaries. Data were analysed using a mixed model for repeated measures ANOVA and Pearson’s Chi-Square test. The need for rescue analgesia differed significantly between the two groups (p < 0.0005). In GNS, 89.47% (17/19) of the dogs required rescue analgesia, compared to 10.53% (2/19) of the dogs in GL. The relative risk of rescue for the GNS compared to the GL was approximately 8.5. In conclusion, intraoperative analgesia during ovariohysterectomies in dogs can be enhanced using a lidocaine 2% splash block combined with massage of the ovarian suspensory ligament. Full article
(This article belongs to the Special Issue Developments in Therapeutic Drugs for Pain Management in Animals)
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