New Insights in Large Animal Neurology

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 778

Special Issue Editors


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Guest Editor
Large Animal Veterinary Teaching Hospital, College of Agronomy and Veterinary Medicine, Universidade de Brasília, Brasília 70636-200, Distrito Federal, Brazil
Interests: neurology; cerebrospinal fluid analysis; toxicology; neuropathology; livestock

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Guest Editor
Faculty of Agronomy and Veterinary Medicine, University of Brasília, Brasília 70910-900, Brazil
Interests: neuropathology; toxicology; toxic plants; neoplasms ; immunohistochemistry

Special Issue Information

Dear Colleagues,

The last decade has witnessed significant progress in the diagnosis of neurological diseases in large animals, especially due to the refinement of clinical examination, imaging, pathological and genetic exams, and serological and molecular tests.

We are pleased to invite you to contribute to this Special Issue entitled “New Insights in Large Animal Neurology”, which aims to gather original papers, literature reviews and case reports that address recent advances concerning large animal neurology. The scope of this Special Issue includes, but is not limited to, the following topics:

  • Congenital, genetic and familial disorders;
  • Infectious, inflammatory and immune diseases;
  • Physical and chemical causes;
  • Toxic diseases;
  • Nutritional and metabolic diseases;
  • Neoplasms and other tumors causing neurological disturbances.

We look forward to receiving your contributions.

Best regards,

Dr. Antonio Carlos Lopes Câmara
Prof. Dr. Márcio Botelho de Castro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurologic evaluation
  • ancillary diagnostics aids
  • neuropathology
  • imaging exams
  • cerebrospinal fluid analysis

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Published Papers (1 paper)

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Research

12 pages, 4964 KB  
Article
Pituitary Abscess Syndrome in Ruminants: Nine Cases
by Gabriele Maroneze, Liz de Albuquerque Cerqueira, José Renato Junqueira Borges, Márcio Botelho de Castro and Antonio Carlos Lopes Câmara
Animals 2025, 15(18), 2692; https://doi.org/10.3390/ani15182692 - 15 Sep 2025
Viewed by 467
Abstract
Pituitary abscess syndrome (PAS) is a rare neurological disorder, typically associated with progressive dysfunction of the cerebrum and brainstem. Reporting PAS in ruminants is essential to broaden the global veterinary understanding of this condition. The present study describes the epidemiological, clinical, laboratory, microbiological, [...] Read more.
Pituitary abscess syndrome (PAS) is a rare neurological disorder, typically associated with progressive dysfunction of the cerebrum and brainstem. Reporting PAS in ruminants is essential to broaden the global veterinary understanding of this condition. The present study describes the epidemiological, clinical, laboratory, microbiological, and pathological findings of nine ruminant cases diagnosed with PAS. Neurological signs were the most prominent clinical manifestations and included altered mentation, tongue hypotonia, nystagmus, blindness, ear ptosis, circling, facial hypoalgesia, head pressing, and proprioceptive deficits. Hematological alterations in some animals comprised leukocytosis by neutrophilia, a degenerative left shift, and hyperfibrinogenemia. Serum biochemical abnormalities were inconsistent and varied among cases. Cerebrospinal fluid (CSF) analysis revealed marked variability, ranging from normal parameters to mild or marked pleocytosis, often accompanied by hyperproteinorrachia. Microbiological cultures from CSF samples or abscess material yielded Trueperella pyogenes, Streptococcus spp., and Corynebacterium spp. Gross pathological findings primarily included pituitary hyperemia, abscess formation, or diffuse suppurative inflammation characterized by a creamy yellow to greenish exudate. Histopathological examination revealed severe multifocal suppurative inflammation composed predominantly of neutrophils, occasional histiocytes, abundant bacteria, areas of necrosis, and encapsulated abscesses. This retrospective study provides novel insights into the clinical, laboratory, and pathological characteristics of PAS in ruminants under field conditions, thereby contributing to improved recognition and diagnostic understanding of this uncommon disease. Full article
(This article belongs to the Special Issue New Insights in Large Animal Neurology)
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