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Use of Antioxidants as Feed Additives to Enhance Farm Animal Production

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: closed (31 January 2026) | Viewed by 2236

Editor


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Guest Editor
Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland
Interests: microelements; selenium; selenitetriglyceride; ruminants; antioxidants; nutrition
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Special Issue Information

Dear Colleagues,

Intensive biochemical processes occurring in the bodies of highly productive animals result in a significant increase in oxygen demand. The consequence of these transformations is the production of significant amounts of free oxygen radicals (FOR) and other reactive oxygen species (ROS). Under homeostasis conditions, reactive oxygen species are constantly inactivated by antioxidants of both endogenous and exogenous origin. An increase in the production of free radicals, a decrease in the amount of antioxidants, and a decrease in the activity of enzymatic systems responsible for the removal of ROS mean that they are not effectively eliminated from the body. The balance is disturbed, and pro-oxidant processes outweigh antioxidant processes, which is called oxidative stress. Farm animals are highly exposed to oxidative stress. The main factors inducing the formation of reactive oxygen species comprise the perinatal period, pregnancy, poor quality of the feed ration, high environmental temperatures, diseases, infections, and physical exertion. The long-term impact of oxidative stress is associated with damage to proteins, lipids, and DNA in the cells of the body. As a result, the general health status of animals is disturbed, production results (e.g., weight gain and feed utilization) and the quality of animal products deteriorate. Adding antioxidant substances to feed mixtures may be a type of prophylaxis, protecting against the adverse effects of free radicals.

Dr. Katarzyna Żarczyńska
Guest Editor

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Keywords

  • antioxidants
  • nutrition
  • farm animals
  • production
  • microelements
  • herbs
  • vitamins
  • oxidative stress
  • free oxygen radicals
  • reactive oxygen species

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Published Papers (1 paper)

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Review

37 pages, 499 KB  
Review
The Role of Selenium in the Antioxidant System of Cattle, Pigs, and Small Ruminants: Implications for Animal Health and Productivity
by Katarzyna Żarczyńska, Katarzyna Różańska, Oliwia Świerczek and Dawid Tobolski
Animals 2026, 16(7), 1019; https://doi.org/10.3390/ani16071019 - 26 Mar 2026
Cited by 3 | Viewed by 1602
Abstract
Oxidative stress contributes to reproductive disorders, immune dysfunction, and reduced productivity in livestock during periods of high metabolic demand and environmental challenge. Selenium supports antioxidant defense systems because it is incorporated as selenocysteine into selenoproteins, including glutathione peroxidases and thioredoxin reductases that detoxify [...] Read more.
Oxidative stress contributes to reproductive disorders, immune dysfunction, and reduced productivity in livestock during periods of high metabolic demand and environmental challenge. Selenium supports antioxidant defense systems because it is incorporated as selenocysteine into selenoproteins, including glutathione peroxidases and thioredoxin reductases that detoxify peroxides and sustain redox balance. The review summarizes selenium occurrence and chemical forms in feeds, as well as its absorption, transportation, and storage. The review also outlines the major features of selenoprotein biosynthesis and its prioritized allocation, with an emphasis on cattle, pigs, sheep, and goats. Evidence from multiple sources indicates that selenium status and supplementation interacts with antioxidant capacity, immune competence, thyroid hormone metabolism, reproductive performance, and the transfer of selenium to milk and offspring. In ruminants, rumen microbial transformations can reduce the bioavailability of inorganic selenium salts, and organic sources, such as selenium-enriched yeast, hydroxy-selenomethionine, and selenitetriglycerides, often increase blood and milk selenium more effectively. In pigs, organic selenium is commonly associated with enhanced antioxidant and immune indices in sows and piglets during late gestation, lactation, and weaning, whereas effects on growth performance are inconsistent. The review emphasizes the narrow margin between adequacy and excess and outlines practical considerations for supplementation and monitoring, alongside research needs for emerging selenium forms and functional biomarkers. Full article
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