Osteosarcoma in Companion Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 1492

Special Issue Editor


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Guest Editor
Faculty of veterinary Medicine, University Lusófona, 1749-024 Lisbon, Portugal
Interests: veterinary oncology; comparative oncology; carcinoma; cancer; osteosarcoma; bone tumors

Special Issue Information

Dear Colleagues,

Osteosarcoma is the most common malignant bone tumor found in dogs. Indeed, while much less common in cats, it still accounts for around 70% of cancerous bone tumors in felines.

The present standard of care includes surgery and adjuvant medical therapy and offers a survival time of around one year, with metastatic disease being the principal cause of death in dogs. Metastatic spread in cats is rarer than in dogs. As such, surgical intervention, when it is possible, can allow feline osteosarcoma patients to live relatively normally after surgical treatment.

Despite the significant improvements in canine veterinary oncology regarding tumor prevention, early detection, diagnosis, and treatment made over recent decades, unfortunately for dogs affected by osteosarcoma, these advances have not changed the therapeutic and prognostic landscape as considerably as in other canine cancers.

Herein, we invite scholars to submit original research and review papers that discuss novel and innovative approaches to the diagnosis, staging, treatment, and comparative aspects of osteosarcoma in companion animals to this Special Issue, which aims to highlight potential areas of interest for future research questions.

Prof. Dr. Joaquim Henriques
Guest Editor

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Keywords

  • osteosarcoma
  • bone tumor
  • companion animal
  • dog
  • canine
  • cat
  • feline
  • sarcoma

Published Papers (1 paper)

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10 pages, 2958 KiB  
Case Report
Vertebral Osteosarcoma in Two Cats—Diagnosis, Treatment, and Outcome
by Koen Maurits Santifort, Martijn Beukers, Arno Roos, Benjamin van Rijswoud, Nadine Meertens, Klaas Peperkamp, Ron Ben-Amotz and Niklas Bergknut
Animals 2023, 13(22), 3478; https://doi.org/10.3390/ani13223478 - 10 Nov 2023
Viewed by 1073
Abstract
In this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and [...] Read more.
In this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and vertebral column revealed a strongly contrast-enhancing mass lesion originating from the dorsal lamina and spinous process of T13. The lesion caused extradural compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation of surgical biopsies was consistent with vertebral osteosarcoma. The cat was paraplegic with intact nociception post-surgery. Subsequently, the cat recovered ambulation while remaining mildly ataxic and paraparetic at long-term follow-up. Post-operative chemotherapy was started with doxorubicin. CT scans at 2, 4, 9, 13, and 20 months post-surgery showed no signs of local recurrence or metastasis. Case 2: A 15.5-year-old male neutered domestic shorthaired cat was presented with progressive paraparesis, tail paresis, and spinal hyperesthesia. Radiographs and CT scan of the lumbar vertebral column showed a large mass originating from the dorsal lamina and spinous process of L6, suggestive of neoplasia, with severe compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation was consistent with vertebral osteosarcoma. Post-operative chemotherapy was started with doxorubicin. Seven months post-surgery, the patient was neurologically normal with no signs of metastatic disease. This case report highlights the possibility of good outcomes after the surgical treatment of feline vertebral osteosarcoma supplemented with post-surgical chemotherapy. Full article
(This article belongs to the Special Issue Osteosarcoma in Companion Animals)
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