Anaesthesia and Analgesia in Laboratory Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 767

Special Issue Editors


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Guest Editor
Department of veterinary medical sciences, University of Bologna, Ozzano dell’Emilia, Italy
Interests: veterinary anaesthesia and analgesia; laboratory animal medicine

E-Mail Website
Guest Editor
Department of veterinary medical sciences, University of Bologna, Ozzano dell’Emilia, Italy
Interests: physiology of reproduction; translational medicine; animal models
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Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to highlight the most recent advancements in anaesthesia and analgesia for laboratory animals.

Biomedical research involves several animal species including rodents, rabbits, fishes, amphibians, reptiles, birds, ruminants, swine, dogs and cats, and non-human primates. Anaesthesia or analgesic treatment in these animals is required in several situations, either correlated with the experimental procedures or with the clinical conditions of the animals. In these cases, the anaesthetic and analgesic approach should consider not only the species-specific characteristics, in some cases the peculiarities of the strain, but also the objectives and the requirements of the research protocol. It is now widely recognised that the refinement of the anaesthesia and analgesia is crucial not only for ensuring animal wellbeing, but also for high-quality research outcomes.

We therefore invite the submission of original studies, case reports, or reviews focusing on anaesthesia and analgesia, including loco-regional anaesthetic techniques, specifically refined for laboratory animal species.

Dr. Carlotta Lambertini
Dr. Domenico Ventrella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • analgesia
  • anesthesia
  • animal models
  • biomedical research
  • experimental surgery
  • refinement
  • translational medicine
  • 3Rs

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Published Papers (1 paper)

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Research

15 pages, 896 KiB  
Article
Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery
by Daniela Casoni, Chiara Parodi, Luisana Gisela Garcia Casalta, Kay Nettelbeck and Claudia Spadavecchia
Animals 2025, 15(13), 1843; https://doi.org/10.3390/ani15131843 - 22 Jun 2025
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Abstract
Buprenorphine has gained widespread popularity for use in rabbits, while much less is known about methadone. Our aim was to compare sedative, analgesic, and respiratory effects of methadone and buprenorphine as part of balanced anaesthesia. Forty-eight female New Zealand white rabbits undergoing calvaria [...] Read more.
Buprenorphine has gained widespread popularity for use in rabbits, while much less is known about methadone. Our aim was to compare sedative, analgesic, and respiratory effects of methadone and buprenorphine as part of balanced anaesthesia. Forty-eight female New Zealand white rabbits undergoing calvaria defects were randomly equally assigned to receive either 0.03 mg kg−1 of buprenorphine (group B) or 0.3 mg kg−1 of methadone (group M) in combination with 15 mg kg−1 of ketamine and 0.1 mg kg−1 of dexmedetomidine SC. Fifteen minutes later, sedation was scored. A laryngeal mask was placed, and inhalational anaesthesia started. Rescue intraoperative analgesia was administered based on autonomic variations. Arterial blood gases were analysed intra- and postoperatively. Postoperative analgesia was administered if the Rabbit Grimace Scale (RbtGS) score was ≥4. The Mann–Whitney test, t-test, and relative risk followed by chi-square test were used to compare the treatment groups. Deeper sedation was observed in rabbits of group M than in those of group B. Rescue analgesia was administered intraoperatively to seven animals in group B and five in group M (p = 0.739) and postoperatively to three in group B and twelve in group M (p = 0.013). Rabbits of both groups showed short-term respiratory acidosis. RbtGS scores indicated better and longer analgesia in group B compared to group M. Full article
(This article belongs to the Special Issue Anaesthesia and Analgesia in Laboratory Animals)
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