Advances in Animal Poisoning and Investigative Diagnostic Toxicology: Mechanisms, Detection, and Intervention

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 835

Special Issue Editor


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Guest Editor
Institutes of Agricultural Science and Technology Development (Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China), College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: animal metabolism; animal nutrition; bone; heavy metal; blood; public health
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Special Issue Information

Dear Colleagues,

Animal poisoning poses significant risks to wildlife, livestock, companion animals, and ecosystems, necessitating precise diagnostic strategies and evidence-based interventions. This Special Issue synthesizes current advancements in investigative diagnostic toxicology, focusing on the identification of toxicants (e.g., pesticides, heavy metals, plant alkaloids, and mycotoxins), mechanistic insights into toxin–pathway interactions, and cutting-edge analytical methodologies. Importantly, the current Special Issue will also accept basic research papers related to veterinary toxicology. Key topics include the application of advanced laboratory techniques—such as mass spectrometry (LC-MS/MS), immunoassays, and molecular biomarkers—for rapid toxicant identification in biological matrices (blood, urine, and tissues). Case studies should highlight the integration of clinical symptomatology, postmortem findings, and environmental forensics to resolve complex poisoning scenarios, including accidental exposures, malicious intoxications, and ecological contamination events. Emerging technologies, such as metabolomics and biosensor-based platforms, will be discussed for their potential to enhance sensitivity and specificity in toxin detection. Additionally, this review will address species-specific vulnerabilities, antidote development, and preventive measures tailored to veterinary and wildlife conservation contexts. By bridging gaps between clinical toxicology, forensic science, and environmental health, this work will emphasize the critical role of multidisciplinary collaboration in mitigating poisoning risks and improving therapeutic outcomes.

Dr. Xishuai Tong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • toxicology
  • in vitro toxicity models
  • environmental pollutants
  • agricultural toxicants
  • toxicity of nanomaterials
  • toxicogenomics and epigenetics
  • applications of artificial intelligence in poisoning diagnosis
  • toxicological risk assessment models
  • cross-species toxic transmission
  • biotoxins produced by drug-resistant bacteria

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Published Papers (1 paper)

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Research

18 pages, 4759 KB  
Article
Polystyrene Nanoplastics Exposure Alters Gut Microbiota and Correlates with Egg Quality Parameters in Chickens
by Xuan Hu, Yinyin Liu, Wanqiang Chen, Yinping Ma, Yanfeng Fan, Qian Zhou, Mengmeng Lei, Hongsheng Song, Min Zhao, Xiaoxu Jia, Guodong Cai, Jianchun Bian and Yushi Gao
Animals 2025, 15(21), 3154; https://doi.org/10.3390/ani15213154 - 30 Oct 2025
Viewed by 340
Abstract
NPs have become a concerning global environmental problem. Dietary exposure to NPs can cause microbial dysbiosis. However, the risks of NPs to animals, particularly poultry species such as chickens, remain poorly understood. In this study, chickens were continuously exposed to 100 nm NPs [...] Read more.
NPs have become a concerning global environmental problem. Dietary exposure to NPs can cause microbial dysbiosis. However, the risks of NPs to animals, particularly poultry species such as chickens, remain poorly understood. In this study, chickens were continuously exposed to 100 nm NPs via dietary inclusion from 18 weeks of age for 120 days to evaluate the effects of NPs on intestinal health. We found that NPs accumulated in chicken intestinal tissues, leading to adverse alterations in the intestinal mucosal structure, such as villus atrophy and goblet cell depletion, and significantly altering intestinal length. The 16S rRNA sequencing revealed significant gut microbiota dysbiosis, characterized by a loss of diversity and shifts in key bacterial groups. Functional predictions of the microbiota revealed impairments in metabolic pathways, especially carbohydrate and amino acid metabolism. Furthermore, network analysis showed that microbial interactions were disrupted and key functional hubs were lost. Most importantly, NPs exposure led to a significant decline in egg quality parameters, including eggshell thickness and strength, yolk color, weight, shape index, and Haugh units. Correlation analyses connected specific taxa, such as Methanobrevibacter, Rikenellaceae_RC9_gut_group, and Prevotellaceae_UCG-001, to intestinal damage and declines in egg quality. These findings provide a scientific basis for assessing the health risks of NPs in animals and offer insights into the development of gut health interventions. Full article
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