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5.2
2.7
Journals
Animals
Special Issues
Animal Pain Management: Insights Across Companion, Farm, and Laboratory Animals
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Animal Pain Management: Insights Across Companion, Farm, and Laboratory Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 576

Special Issue Editors

Dr. Caterina Di Bella

E-Mail Website
Guest Editor
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00173 Rome, Italy
Interests: anesthesia; pain management; loco-regional anaesthesia; laboratory animals
Dr. Luca Pennasilico

E-Mail Website
Guest Editor
School of Bioscience and Veterinary Medicine, University of Camerino, 62024 Matelica, Italy
Interests: osteoarthritis management; chronic pain; orthopedic surgery; regenerative therapies
Special Issues, Collections and Topics in MDPI journals
Dr. Elisa Silvia D'Urso

E-Mail Website
Guest Editor
1. Independent Researcher, Rome, Italy
2. Mindray Animal Medical Technology Co., Ltd., Shenzhen, China
Interests: small animals anesthesia; exotic anesthesia; pain management; loco-regional anesthesia

Special Issue Information

Dear Colleagues,

Pain is a negative and unpleasant experience, and can be associated with the presence of tissue damage. In veterinary medicine, its management is complicated by the inability of animals to communicate their suffering as humans do. Scientific research is constantly advancing, allowing ways to better understand the main pathogenic mechanisms of pain. There is a search for new and valid diagnostic tools, as well as effective therapies that guarantee good efficacy with few side effects, in different animal species.

Based on this background, our goal is to present the most recent and innovative research conducted in veterinary medicine, with the aim of expanding knowledge in the field of pain management.

Dr. Caterina Di Bella
Dr. Luca Pennasilico
Dr. Elisa Silvia D'Urso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nociception
  • pain management
  • loco-regional anesthesia
  • analgesic therapies
  • regenerative medicine
  • small animals
  • large animals
  • laboratory animals

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

13 pages, 254 KB  
Article
Lack of Effectiveness of Tramadol for Earlier Limb Weight-Bearing After Femoral Head and Neck Excision in 38 Dogs
by Androniki Krystalli, George M. Kazakos, Ioannis Savvas and Nikitas N. Prassinos
Animals 2026, 16(7), 1064; https://doi.org/10.3390/ani16071064 - 31 Mar 2026
Viewed by 277
Abstract
The objective of this study was to evaluate, in client-owned dogs, the postoperative analgesic efficacy of the centrally acting analgesic tramadol following femoral head and neck excision (FHNE). Thirty-eight dogs were diagnosed with coxofemoral disease and underwent FHNE. The sample was randomly divided [...] Read more.
The objective of this study was to evaluate, in client-owned dogs, the postoperative analgesic efficacy of the centrally acting analgesic tramadol following femoral head and neck excision (FHNE). Thirty-eight dogs were diagnosed with coxofemoral disease and underwent FHNE. The sample was randomly divided into two groups. Postoperatively, dogs in Group A received robenacoxib (2 mg kg−1 bodyweight, sid, per os) until they achieved final weight-bearing of the operated limb, whereas dogs in Group B received the same regimen of robenacoxib in combination with tramadol (5 mg kg−1 bodyweight, tid, per os) for fifteen days. All animals were premedicated, sedated, and anesthetized following the same standardized protocol to ensure consistency between groups. Postoperative evaluations were conducted on days 15 and 30, and subsequently at monthly intervals, until full weight-bearing of the affected limb was achieved. Clinical assessments included observation of pain-related behaviors, lameness scoring, and time to initial weight-bearing (TIWB) and time to final weight-bearing (TFWB). Data normality was assessed using the Shapiro–Wilk test, and differences between groups were evaluated using the independent samples T-test (p = 0.05). Statistical analysis revealed no significant differences between the two groups regarding time to initial (p = 0.087) or final weight-bearing. However, a moderate effect size (d = 0.570) was observed for TIWB, suggesting a clinically interesting trend toward faster early recovery in the multimodal group. These findings indicate that while adding tramadol did not confer a statistically significant additional advantage in this study, the observed clinical trend warrants further investigation in larger, higher-powered cohorts to determine its definitive clinical impact. Full article
(This article belongs to the Special Issue Animal Pain Management: Insights Across Companion, Farm, and Laboratory Animals)
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