Application of Gene-Editing Technology in Porcine Viral Diseases

Dear Colleagues,

Porcine viral diseases—such as African swine fever, porcine reproductive and respiratory syndrome (PRRS), and porcine epidemic diarrhea (PED)—pose significant threats to global pig production, animal welfare, and food security. Traditional control strategies, including vaccination and biosecurity, have limitations in efficacy and sustainability. Recent advances in gene-editing technologies, particularly CRISPR-Cas systems, offer promising avenues for developing disease-resistant pigs by precisely modifying host genes involved in viral entry or immune response.

This Special Issue aims to present original research articles and comprehensive reviews that explore the application of gene-editing tools to understand, prevent, or mitigate porcine viral infections. Topics may include functional genomics of host–virus interactions, generation of genetically edited pig models, ethical and regulatory considerations, and translational potential in commercial swine production. The scope aligns with Agriculture’s focus on innovative, sustainable solutions in farm animal health and productivity.

We welcome contributions that bridge molecular biology, veterinary science, and agricultural biotechnology to advance resilient pig farming systems.

Prof. Dr. Yongtao Li
Guest Editor

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