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Review

Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia

Paul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow G120ZD, UK
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Author to whom correspondence should be addressed.
Academic Editors: Ugo Testa and Roland B. Walter
Hemato 2021, 2(3), 556-571; https://doi.org/10.3390/hemato2030035
Received: 14 July 2021 / Revised: 17 August 2021 / Accepted: 23 August 2021 / Published: 27 August 2021
(This article belongs to the Special Issue Current Topics in Acute Myeloid Leukemia)
Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell cycle and differentiation in the myeloid lineage. Recent evidence has demonstrated that NFAT family members may have roles in regulating AML leukemogenesis and resistance to targeted therapy in myeloid leukaemia. Furthermore, gene expression data from patient samples show that some NFATs are more highly expressed in poorly differentiated AML and after disease relapse, implying that the NFAT family may have roles in specific types of AML. This review outlines the evidence for the role of NFAT in healthy myeloid tissue and explores how NFAT might regulate AML pathogenesis, highlighting the potential to target specific NFAT proteins therapeutically in AML. View Full-Text
Keywords: leukaemia; NFAT; myeloid; cell cycle; differentiation; AML leukaemia; NFAT; myeloid; cell cycle; differentiation; AML
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MDPI and ACS Style

Patterson, S.D.; Huang, X.; Jørgensen, H.G.; Michie, A.M. Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia. Hemato 2021, 2, 556-571. https://doi.org/10.3390/hemato2030035

AMA Style

Patterson SD, Huang X, Jørgensen HG, Michie AM. Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia. Hemato. 2021; 2(3):556-571. https://doi.org/10.3390/hemato2030035

Chicago/Turabian Style

Patterson, Shaun D., Xu Huang, Heather G. Jørgensen, and Alison M. Michie 2021. "Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia" Hemato 2, no. 3: 556-571. https://doi.org/10.3390/hemato2030035

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