- Article
The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity
- Mitchell R. McGill,
- Yihong Kaufmann,
- Francesca V. LoBianco,
- Mary A. Schleiff,
- Nukhet Aykin-Burns and
- Grover P. Miller
Tyrosine kinase inhibitors (TKIs) are increasingly popular drugs used to treat more than a dozen different diseases including some forms of cancer. Despite having fewer adverse effects than traditional chemotherapies, they are not without risks. Live...