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Livers, Volume 3, Issue 2

June 2023 - 11 articles

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Cover Story: Development of ascites is a defining feature of decompensated liver cirrhosis, and spontaneous bacterial peritonitis is the most frequent bacterial infection occurring in this patient group. Recent studies of ascitic fluid have revealed quantitative, phenotypic and functional differences in both innate and adaptive immune cells compared to the healthy state. This review summarises the current knowledge of these alterations and explores how the peritoneum in chronic liver disease is simultaneously an immunologically compromised site and yet capable of provoking an intense inflammatory response. A better understanding of this might enable the identification of new therapeutic targets aimed at rebalancing the peritoneal immunity and reducing the reliance on antimicrobials in an era of increasing antimicrobial resistance. View this paper

Articles (11)

  • Article
  • Open Access
9 Citations
3,395 Views
12 Pages

The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity

  • Mitchell R. McGill,
  • Yihong Kaufmann,
  • Francesca V. LoBianco,
  • Mary A. Schleiff,
  • Nukhet Aykin-Burns and
  • Grover P. Miller

19 June 2023

Tyrosine kinase inhibitors (TKIs) are increasingly popular drugs used to treat more than a dozen different diseases including some forms of cancer. Despite having fewer adverse effects than traditional chemotherapies, they are not without risks. Live...

  • Review
  • Open Access
7 Citations
5,839 Views
10 Pages

9 June 2023

Liver regeneration is a compensatory response to tissue injury and loss. It is known that liver regeneration plays a crucial role in recovery following acetaminophen (APAP)-induced hepatotoxicity, which is the major cause of acute liver failure (ALF)...

  • Book Review
  • Open Access
2,179 Views
7 Pages

29 May 2023

Hepatic stellate cells (HSCs) are a liver-specific mesenchymal cell type located in the Dissé space between hepatocytes and sinusoidal endothelial cells [...]

  • Article
  • Open Access
1 Citations
2,285 Views
11 Pages

Expression of Bone Morphogenetic Protein 14 in Liver Disease and Cancer

  • Judith Sommer,
  • Wolfgang E. Thasler,
  • Anja Bosserhoff and
  • Claus Hellerbrand

25 May 2023

The activation of hepatic stellate cells (HSCs) is the key event of hepatic fibrosis. Furthermore, activated HSCs also play an important role in the progression of hepatocellular cancer (HCC). Bone morphogenetic protein 14 (BMP14) is a member of the...

  • Article
  • Open Access
8 Citations
6,134 Views
11 Pages

Prevalence and Trends in Hepatitis B & C Virus among Blood Donors in Pakistan: A Regional Transfusion Center Study

  • Tehreem Zorob,
  • Muhammad Awais Farooqi,
  • Ali Ahsan,
  • Abdullah Zaki,
  • Muhammad Ali Rathore and
  • Hafiz Muhammad Umer Farooqi

17 May 2023

Around 118.5 million blood donations are collected annually to save precious lives. The donated blood may also be associated with blood-borne infections. With around 247 million population, Pakistan is an endemic country for viral hepatitis, and ther...

  • Article
  • Open Access
7 Citations
3,353 Views
13 Pages

Effect of Bergamot Leaves (Citrus bergamia) in the Crosstalk between Adipose Tissue and Liver of Diet-Induced Obese Rats

  • Juliana Silva Siqueira,
  • Erika Tiemi Nakandakare-Maia,
  • Taynara Aparecida Vieira,
  • Thiago Luiz Novaga Palacio,
  • Núbia Alves Grandini,
  • Matheus Antônio Filiol Belin,
  • Gisele Alborghetti Nai,
  • Fernando Moreto,
  • Alessandra Altomare and
  • Giovanna Baron
  • + 3 authors

11 May 2023

The excessive consumption of diets rich in sugar and fat is associated with metabolic manifestations involving adipose tissue and the liver. Bergamot, due to its antioxidant and anti-inflammatory properties, has been used to treat metabolic disorders...

  • Review
  • Open Access
6,740 Views
18 Pages

Peritoneal Immunity in Liver Disease

  • Joseph Delo,
  • Daniel Forton,
  • Evangelos Triantafyllou and
  • Arjuna Singanayagam

26 April 2023

The peritoneum represents a confined microenvironment that has an emerging role as a distinct immunological compartment. In health, this niche is mainly populated by a heterogenous group of macrophages and T lymphocytes but also Natural Killer cells...

  • Communication
  • Open Access
2 Citations
4,231 Views
8 Pages

Chronicles of HBV and the Road to HBV Cure

  • Rukaiya Bashir Hamidu,
  • Richard R. Hann and
  • Hie-Won Hann

20 April 2023

Chronic hepatitis B remains a major public health concern and a leading cause of morbidity and mortality worldwide, specifically through its causative role in chronic liver disease and hepatocellular carcinoma. Worldwide, it affects up to 292 million...

  • Review
  • Open Access
17 Citations
4,994 Views
13 Pages

10 April 2023

Mitochondria are critical organelles responsible for the maintenance of cellular energy homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for energy-intensive metabolic function, such as hepatocytes. Extensive res...

  • Review
  • Open Access
9 Citations
27,319 Views
29 Pages

Principles of Nutritional Management in Patients with Liver Dysfunction—A Narrative Review

  • Essam Mohamed Elsebaie,
  • Alyaa Nasr Abdel-Fattah,
  • Nagwa Awad Bakr,
  • Kadry Mohamed Attalah and
  • Abdel-Hady Ahmed Aweas

4 April 2023

According to studies, the liver’s ability to perform its physiological functions in the body determines the diet of patients with liver diseases. Malnutrition results from the liver’s inability to metabolize nutrients as a result of chron...

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