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Volume 3
Issue 2
10.3390/livers3020012
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Review

An Updated Review on Advances in Hydrogel-Based Nanoparticles for Liver Cancer Treatment

by
Bahareh Farasati Far
1,
Ali Attaripour Isfahani
2,
Elnaz Nasiriyan
2,
Ali Pourmolaei
3,
Golnaz Mahmoudvand
4,5,
Arian Karimi Rouzbahani
4,5,
Mohammed Namiq Amin
6 and
Mohammad Reza Naimi-Jamal
1,*
1
Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran
2
Department of Biological Science and Technology, Najafabad Branch, Islamic Azad University, Najafabad 8514143131, Iran
3
Chemical Engineering Department, Babol Noshirvani University of Technology Shariati Ave, Babol 47148-71167, Iran
4
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad 6718773654, Iran
5
USERN Office, Lorestan University of Medical Sciences, Khorramabad 6718773654, Iran
6
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
*
Author to whom correspondence should be addressed.
Livers 2023, 3(2), 161-189; https://doi.org/10.3390/livers3020012
Submission received: 26 December 2022 / Revised: 28 January 2023 / Accepted: 24 February 2023 / Published: 27 March 2023
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Abstract

More than 90% of all liver malignancies are hepatocellular carcinomas (HCCs), for which chemotherapy and immunotherapy are the ideal therapeutic choices. Hepatocellular carcinoma is descended from other liver diseases, such as viral hepatitis, alcoholism, and metabolic syndrome. Normal cells and tissues may suffer damage from common forms of chemotherapy. In contrast to systemic chemotherapy, localized chemotherapy can reduce side effects by delivering a steady stream of chemotherapeutic drugs directly to the tumor site. This highlights the significance of controlled-release biodegradable hydrogels as drug delivery methods for chemotherapeutics. This review discusses using hydrogels as drug delivery systems for HCC and covers thermosensitive, pH-sensitive, photosensitive, dual-sensitive, and glutathione-responsive hydrogels. Compared to conventional systemic chemotherapy, hydrogel-based drug delivery methods are more effective in treating cancer.
Keywords: hepatocellular carcinoma; liver cancer; hydrogel; controlled-release; drug delivery systems hepatocellular carcinoma; liver cancer; hydrogel; controlled-release; drug delivery systems

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MDPI and ACS Style

Farasati Far, B.; Isfahani, A.A.; Nasiriyan, E.; Pourmolaei, A.; Mahmoudvand, G.; Karimi Rouzbahani, A.; Namiq Amin, M.; Naimi-Jamal, M.R. An Updated Review on Advances in Hydrogel-Based Nanoparticles for Liver Cancer Treatment. Livers 2023, 3, 161-189. https://doi.org/10.3390/livers3020012

AMA Style

Farasati Far B, Isfahani AA, Nasiriyan E, Pourmolaei A, Mahmoudvand G, Karimi Rouzbahani A, Namiq Amin M, Naimi-Jamal MR. An Updated Review on Advances in Hydrogel-Based Nanoparticles for Liver Cancer Treatment. Livers. 2023; 3(2):161-189. https://doi.org/10.3390/livers3020012

Chicago/Turabian Style

Farasati Far, Bahareh, Ali Attaripour Isfahani, Elnaz Nasiriyan, Ali Pourmolaei, Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Mohammed Namiq Amin, and Mohammad Reza Naimi-Jamal. 2023. "An Updated Review on Advances in Hydrogel-Based Nanoparticles for Liver Cancer Treatment" Livers 3, no. 2: 161-189. https://doi.org/10.3390/livers3020012

APA Style

Farasati Far, B., Isfahani, A. A., Nasiriyan, E., Pourmolaei, A., Mahmoudvand, G., Karimi Rouzbahani, A., Namiq Amin, M., & Naimi-Jamal, M. R. (2023). An Updated Review on Advances in Hydrogel-Based Nanoparticles for Liver Cancer Treatment. Livers, 3(2), 161-189. https://doi.org/10.3390/livers3020012

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