Liraglutide and Exercise: A Possible Treatment for Obesity?
, Guilherme Domingos Brisque 1, Gabriela Ferreira Abud 2 and José Rodrigo Pauli 1,3,*
Round 1
Reviewer 1 Report
This a real good review of differents papers and datas
The graphs are correct
Conclusions are shorts but correct
But could be improve with compare papers only liraglutida and only exercise?
If possible adds references about posible differences between luraglutide oral or subcutaneous?
And pediatric studies?
Author Response
Dear Editor,
Firstly, we would like to thank you for the opportunity to revise our paper. We have read the reviewer's comments and judged the suggestions very appropriately. We are confident that the edits within this revision have not only satisfied the reviewer's concerns but have significantly improved the manuscript. We hope that our efforts are evident from the responses below and the revised manuscript. All changes in the current document are highlighted in yellow. Also, we have provided a point-by-point commentary for the reviewer’s comments. We hope our efforts to reach the conditions you have criticized would be enough to have the paper accepted for publication at the Obesities.
Sincerely, José Rodrigo Pauli
Reviewer 1
This a real good review of differents papers and datas
The graphs are correct
Conclusions are shorts but correct
But could be improve with compare papers only liraglutide and only exercise?
We agree with this commentary. We include a topic about physical exercise and obesity treatment in the article (page 3, lines 97-99; Page 3-4, lines 132-152). And the article had a topic about only liraglutide in obesity treatment.
If possible adds references about posible differences between luraglutide oral or subcutaneous?
We agree with this commentary. But we don’t have a reference for the use of oral liraglutide. However include a paragraph comparing liraglutide subcutaneous and oral semaglutide (Page 2, Line 77-84).
And pediatric studies?
We agree with this commentary. The topic was included (Page 5, Lines 195-218).
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This was a well written manuscript. Only a few comments:
1. L26: the conclusion appears to be missing in the abstract. It looks like biolerplate language.
2. This appears to be a review type article to promote Liraglutide and exercise as a treatment for obesity. However, there are only 16 references listed. I did a PubMed search using keywords Liraglutide and exercise and a total of 115 citations appeared. Now I appreciate that all 115 are probably not appropriate, but are some key pieces of literature missing?
3. Having a figure noted in the Conclusion section is not customary. Is there a better location for it? Conclusion section should be wrapping things up, not adding new stuff.
Author Response
August 05, 2022
Dear Editor,
Firstly, we would like to thank you for the opportunity to revise our paper. We have read the reviewer's comments and judged the suggestions very appropriately. We are confident that the edits within this revision have not only satisfied the reviewer's concerns but have significantly improved the manuscript. We hope that our efforts are evident from the responses below and the revised manuscript. All changes in the current document are highlighted in yellow. Also, we have provided a point-by-point commentary for the reviewer’s comments. We hope our efforts to reach the conditions you have criticized would be enough to have the paper accepted for publication at the Obesities.
Sincerely, José Rodrigo Pauli
Reviewer 2
This was a well written manuscript. Only a few comments:
- L26: the conclusion appears to be missing in the abstract. It looks like biolerplate language.
We agree with this commentary. The conclusion was adjusted in the abstract (Page 1, Line 26-29).
- This appears to be a review type article to promote Liraglutide and exercise as a treatment for obesity. However, there are only 16 references listed. I did a PubMed search using keywords Liraglutide and exercise and a total of 115 citations appeared. Now I appreciate that all 115 are probably not appropriate, but are some key pieces of literature missing?
We agree with this commentary. We repeated Search in Pubmed and met 170 articles. However, the majority study is about weight loss in the general context, because this is not included. Finally, most of this article is on a patient with diabetes type 2 and isn’t a review focus, however, it’s correlated with obesity. And we prioritized clinical trials and articles more recents, other articles were included in the text (Page3, Lines 119-123).
- Having a figure noted in the Conclusion section is not customary. Is there a better location for it? Conclusion section should be wrapping things up, not adding new stuff.
We agree with this commentary and changed a figure localization (Page 5, Lines 191-194).
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
They have addressed my prior comments. I appreciate the increase in references
