Central Compartment Atopic Disease as a Pathophysiologically Distinct Subtype of Chronic Rhinosinusitis: A Scoping Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Design
2.1.1. Participants
2.1.2. Information Sources
2.1.3. Search Strategy
2.2. Study Selection
2.3. Data Extraction and Analysis
3. Results
Study | Aim of Study | Study Design and Level of Evidence | Population | Results |
---|---|---|---|---|
White, 2014 [6] | Investigate the association between isolated MT polyps and inhalant allergy | Case series Level 4 | 25 patients with isolated MT polyps |
|
Brunner, 2017 [8] | Compare clinical characteristics of polypoid change of the MT (PCMT) with paranasal sinus polyposis (PSP) | Case series Level 4 | 593 patients: 23 (3.9%) with PCMT and 44 (7.4%) with PSP |
|
DelGaudio, 2017 [3] | Describe a newly recognized variant of CRS, termed CCAD | Case series Level 4 | 15 patients with sinonasal symptoms and CC polypoid mucosal changes |
|
Hamizan, 2017 [7] | Determine the characteristics of MT edema as a marker of inhalant allergy | Cross-sectional Level 4 | 187 patients |
|
Hamizan, 2018 [12] | Identify radiologic patterns in CRS to predict allergic etiology | Cross-sectional Level 4 | 112 patients with CRS |
|
DelGaudio, 2019 [2] | Investigate the role of allergy and surgery in CC involvement in AERD | Retrospective Cohort Level 3 | 72 patients with AERD: 59 (80.6%) had CC polyps/polypoid disease, with 53 bilateral and 6 unilateral |
|
Abdullah, 2020 [14] | Define the clinical and radiological characteristics of the allergic phenotype of CRSwNP | Cross-sectional Level 4 | 38 patients with CRSwNP: 19 with allergy and 19 without allergy |
|
Marcus, 2020 [4] | Determine the prevalence of allergy and asthma in CCAD compared with other CRSwNP subtypes | Retrospective Cohort Level 3 | 356 patients with CRSwNP: 37.1% with CRSwNP NOS, 24.2% with AERD, 23.6% with AFRS, 11.5% with CCAD, and 3.7% with CRSwNP/CC |
|
Roland, 2020 [13] | Evaluate CT findings associated with each CRSwNP phenotype | Retrospective Cohort Level 3 | 356 patients: 23% with AFRS 28% with AERD 12% with CCAD 37% with CRSwNP NOS |
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Lin, 2021 [17] | Investigate the clinical features and cytokine profiles of CCAD in East Asian patients. | Cross-sectional Level 4 | 95 patients: 16 with CCAD and 51 with other CRS subtypes |
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Steehler, 2021 [16] | Evaluate surgical outcomes in CRSwNP subtypes | Retrospective Cohort Level 3 | 132 patients: 38 with CCAD, 20 with AERD, 37 with AFRS, 37 with CRSwNP NOS |
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Warman, 2021 [15] | Compare the inflammatory features of antrochoanal polyps (ACP) to diffuse primary CRSwNP (d-CRS) and its subgroups | Case series Level 4 | 96 patients: 40 (41.6%) with ACP, 36 (37.5%) with d-CRS, and 20 (20.8%) with control (patients undergoing turbinate reduction surgery due to nasal obstructions) |
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Edwards, 2022 [22] | Compare allergen sensitivity of local sinonasal tissue to that of skin and serum in patients with CCAD | Case series Level 4 | 15 participants with CCAD |
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Kong, 2022 [19] | Identify clinical presentations and cellular endotyping diagnosis of Chinese CCAD using artificial intelligence | Retrospective Cohort Level 3 | 79 Patients: 14 with CCAD, 32 with eosinophilic CRSwNP (ENP), and 26 with non-eosinophilic CRSwNP (NENP) |
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Lee, 2022 [23] | Investigate the ability of radiologic studies to predict CCAD in pediatric patients | Retrospective Cohort Level 3 | 82 pediatric patients diagnosed with CRS: 55/82 (67.1%) had aeroallergen sensitization, and 31/164 (18.9%) sides of sinuses had the radiologic CCAD phenotype |
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Nie, 2022 [20] | Describe the clinical manifestations of CCAD and compare to CRSwNP/CC involvement and CRSwNP NOS | Case series Level 4 | 116 patients: 39 with CCAD, 38 with CRSwNP/CC, and 39 with CRSwNP NOS |
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Shih, 2022 [18] | Determine the clinical presentations, risk factors, and surgical outcomes of CCAD in the Asian population | Case control Level 4 | 442 patients with CRSwNP: 51 with CCAD and 391 with lateral-dominant nasal polyp (LDNP) |
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Tripathi, 2022 [21] | Identify allergens associated with CRS endotypes and any relationships between their allergen sensitivity profiles. | Cross sectional Level 4 | 515 patients: 341 with CRS, 174 with AR. Of CRS patients: CRSwNP = 182, CRSsNP = 159. Of CRSwNP: AERD = 15, AFRS = 18, CCAD = 24, CRSwNP NOS = 125 |
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4. Discussion
4.1. Clinical Characteristics
4.1.1. Patient Characteristics
4.1.2. Nasal Endoscopy
4.1.3. Radiologic Imaging
4.1.4. Allergy Testing
4.1.5. Histology and Molecular Findings
4.2. Management and Treatment Outcomes
4.3. Specific Populations
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Abbreviation | Full Name |
---|---|
AFRS | Allergic fungal rhinosinusitis |
AR | Allergic rhinitis |
ACP | Antrochoanal polyps |
AERD | Aspirin-exacerbated respiratory disease |
CC | Central compartment |
CCAD | Central compartment atopic disease |
CRS | Chronic rhinosinusitis |
CRSwNP | Chronic rhinosinusitis with nasal polyps |
CRSsNP | Chronic rhinosinusitis without nasal polyps |
d-CRS | Diffuse primary chronic rhinosinusitis with nasal polyps |
ENP | Eosinophilic chronic rhinosinusitis with nasal polyps |
IgE | Immunoglobulin-E |
LDNP | Lateral-dominant nasal polyp |
LK | Lund–Kennedy |
LM | Lund–Mackay |
MT | Middle turbinate |
NENP | Non-eosinophilic chronic rhinosinusitis with nasal polyps |
PSP | Paranasal sinus polyposis |
PCMT | Polypoid change of the middle turbinate |
SNS | Superior nasal septum |
ST | Superior turbinate |
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Davies, C.; Wu, F.; Huang, E.Y.; Takashima, M.; Rowan, N.R.; Ahmed, O.G. Central Compartment Atopic Disease as a Pathophysiologically Distinct Subtype of Chronic Rhinosinusitis: A Scoping Review. Sinusitis 2023, 7, 12-26. https://doi.org/10.3390/sinusitis7020003
Davies C, Wu F, Huang EY, Takashima M, Rowan NR, Ahmed OG. Central Compartment Atopic Disease as a Pathophysiologically Distinct Subtype of Chronic Rhinosinusitis: A Scoping Review. Sinusitis. 2023; 7(2):12-26. https://doi.org/10.3390/sinusitis7020003
Chicago/Turabian StyleDavies, Camron, Franklin Wu, Emily Y. Huang, Masayoshi Takashima, Nicholas R. Rowan, and Omar G. Ahmed. 2023. "Central Compartment Atopic Disease as a Pathophysiologically Distinct Subtype of Chronic Rhinosinusitis: A Scoping Review" Sinusitis 7, no. 2: 12-26. https://doi.org/10.3390/sinusitis7020003