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Open AccessArticle

Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?

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Clinic of Gastroenterology, Medical Faculty Internal Medicine, Maltepe University, Maltepe 34843, Turkey
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Gastroenterology and Hepatology, Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX 77062, USA
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2019, 1(2), 266-272; https://doi.org/10.3390/gidisord1020022
Received: 19 April 2019 / Revised: 14 May 2019 / Accepted: 20 May 2019 / Published: 31 May 2019
(This article belongs to the Special Issue Colorectal Cancer: Biology and Therapy)
Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. İmpairment of the gut microbiota has been associated with development of colorectal cancer. The genus Bifidobacterium is an important component of the commensal gut microbiota. Bifidobacteria are considered to have important roles in multiple homeostatic functions: immunologic, hormonal and metabolic. Mucosal-associated invariant T cells (MAIT) are components of the immune system involved in protection against infectious pathogens and regulate the pathogenesis of various inflammatory diseases and, potentially, colorectal cancer. Engagement between Bifidobacterium and MAIT cells could exert a beneficial effect on colorectal cancer prevention and treatment. View Full-Text
Keywords: Bifidobacterium; MAIT cells; colorectal cancer Bifidobacterium; MAIT cells; colorectal cancer
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Bozkurt, H.S.; Quigley, E.M.M. Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention? Gastrointest. Disord. 2019, 1, 266-272.

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