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Article

Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?

1
Center for Sleep Medicine and Respiratory Diseases, Hospices Civils de Lyon, 69004 Lyon, France
2
Center for Clinical Research, Hospices Civils de Lyon, 69004 Lyon, France
3
Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, 69000 Lyon, France
4
Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team ‘Biologie vasculaire et du globule rouge’, Lyon 1 University, 69000 Lyon, France
5
Faculty of Medicine Lyon Sud-Charles Mérieux, Lyon 1 University, 69000 Lyon, France
*
Author to whom correspondence should be addressed.
Current Address: Center for Sleep Medicine and Respiratory Diseases, Croix-Rousse Hospital, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France.
Clocks & Sleep 2021, 3(2), 259-273; https://doi.org/10.3390/clockssleep3020016
Received: 29 March 2021 / Revised: 22 April 2021 / Accepted: 27 April 2021 / Published: 30 April 2021
(This article belongs to the Section Disorders)
The interpretation of the Maintenance Wakefulness Test (MWT) relies on sleep onset detection. However, microsleeps (MSs), i.e., brief periods of sleep intrusion during wakefulness, may occur before sleep onset. We assessed the prevalence of MSs during the MWT and their contribution to the diagnosis of residual sleepiness in patients treated for obstructive sleep apnea (OSA) or hypersomnia. The MWT of 98 patients (89 OSA, 82.6% male) were analyzed for MS scoring. Polysomnography parameters and clinical data were collected. The diagnostic value for detecting sleepiness (Epworth Sleepiness Scale > 10) of sleep onset latency (SOL) and of the first MS latency (MSL) was assessed by the area under the receiver operating characteristic (ROC) curve (AUC, 95% CI). At least one MS was observed in 62.2% of patients. MSL was positively correlated with SOL (r = 0.72, p < 0.0001) but not with subjective scales, clinical variables, or polysomnography parameters. The use of SOL or MSL did not influence the diagnostic performance of the MWT for subjective sleepiness assessment (AUC = 0.66 95% CI (0.56, 0.77) versus 0.63 95% CI (0.51, 0.74)). MSs are frequent during MWTs performed in patients treated for sleep disorders, even in the absence of subjective sleepiness, and may represent physiological markers of the wake-to-sleep transition. View Full-Text
Keywords: polysomnography; sleep latency; sleepiness; wakefulness; Maintenance Wakefulness Test polysomnography; sleep latency; sleepiness; wakefulness; Maintenance Wakefulness Test
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MDPI and ACS Style

Des Champs de Boishebert, L.; Pradat, P.; Bastuji, H.; Ricordeau, F.; Gormand, F.; Le Cam, P.; Stauffer, E.; Petitjean, T.; Peter-Derex, L. Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness? Clocks & Sleep 2021, 3, 259-273. https://doi.org/10.3390/clockssleep3020016

AMA Style

Des Champs de Boishebert L, Pradat P, Bastuji H, Ricordeau F, Gormand F, Le Cam P, Stauffer E, Petitjean T, Peter-Derex L. Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness? Clocks & Sleep. 2021; 3(2):259-273. https://doi.org/10.3390/clockssleep3020016

Chicago/Turabian Style

Des Champs de Boishebert, Ludivine, Pierre Pradat, Hélène Bastuji, François Ricordeau, Frédéric Gormand, Pierre Le Cam, Emeric Stauffer, Thierry Petitjean, and Laure Peter-Derex. 2021. "Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?" Clocks & Sleep 3, no. 2: 259-273. https://doi.org/10.3390/clockssleep3020016

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