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Abstract

Moringa arborea-Mediated Iron Oxide Nanoparticles, Their Characterization and Their Anti-Cancer Potential on Highly and Weakly Metastatic Human Breast Cancer Cells †

by
Huzaifa Umar
1,* and
Maryam Rabiu Aliyu
2
1
Operational Research Centre in Healthcare, Near East University, TRNC Mersin 10, Nicosia 99138, Turkey
2
Department of Energy System Engineering, Cyprus International University, TRNC Mersin 10, Nicosia 99138, Turkey
*
Author to whom correspondence should be addressed.
†
Presented at the 3rd International Electronic Conference on Processes—Green and Sustainable Process Engineering and Process Systems Engineering (ECP 2024), 29–31 May 2024; Available online: https://sciforum.net/event/ECP2024.
Proceedings 2024, 105(1), 24; https://doi.org/10.3390/proceedings2024105024
Published: 28 May 2024
(This article belongs to the Proceedings of The 3rd International Electronic Conference on Processes—Green and Sustainable Process Engineering and Process Systems Engineering)
Versions Notes

Iron oxide nanoparticles stabilized with Moringa arborea were synthesized. The study aimed to investigate the cytotoxic potential of IONPs through various assays, such as trypan blue and MTT assays, of the synthesized iron oxide nanoparticles (IONPs). The Moringa arborea-mediated IONPs (M A IONPs) were analyzed using a range of techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy (UV-vis), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). The FTIR, XRD, and SEM-EDX results confirmed the successful synthesis of IONPs. A gas chromatography–mass spectrometry (GC-MS) analysis of the plant revealed various compounds of medicinal value. The analysis of the UV-vis spectra indicates an absorption peak at 314 nm, thereby ensuring both the successful synthesis and remarkable stability of the nanoparticles. The nanoparticles exhibited a uniform spherical morphology and contained Fe, O, N and some minor elements, confirming the formation of IONPs NPs. The cytotoxic potential on MCF-7 and MDA-MB 231 human breast cancer cells was observed with various concentrations of M A IONPs, and the cytotoxicity results revealed an IC50 of 48.7 μg/mL and 54.6 μg/mL, respectively. Stable IONPs were synthesized using a methanolic extract of Moringa arborea. The nanoparticles exhibited cytotoxic potential on highly and weakly metastatic human breast cancer cell lines.

Supplementary Materials

The presentation materials can be downloaded at: https://www.mdpi.com/article/10.3390/proceedings2024105024/s1.

Author Contributions

Conceptualization, H.U. and M.R.A.; methodology, H.U. and M.R.A.; software, H.U. and M.R.A.; validation, H.U. and M.R.A.; formal analysis, H.U.; investigation, H.U.; resources, H.U. and M.R.A.; data curation, H.U. and M.R.A.; writing—original draft preparation, H.U.; writing—review and editing, H.U. and M.R.A.; visualization, H.U. and M.R.A.; supervision, H.U. and M.R.A.; project administration, H.U.; funding acquisition, H.U. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data are contained within this abstract and the poster in the Supplementary Materials.

Conflicts of Interest

The authors declare no conflicts of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Umar, H.; Aliyu, M.R. Moringa arborea-Mediated Iron Oxide Nanoparticles, Their Characterization and Their Anti-Cancer Potential on Highly and Weakly Metastatic Human Breast Cancer Cells. Proceedings 2024, 105, 24. https://doi.org/10.3390/proceedings2024105024

AMA Style

Umar H, Aliyu MR. Moringa arborea-Mediated Iron Oxide Nanoparticles, Their Characterization and Their Anti-Cancer Potential on Highly and Weakly Metastatic Human Breast Cancer Cells. Proceedings. 2024; 105(1):24. https://doi.org/10.3390/proceedings2024105024

Chicago/Turabian Style

Umar, Huzaifa, and Maryam Rabiu Aliyu. 2024. "Moringa arborea-Mediated Iron Oxide Nanoparticles, Their Characterization and Their Anti-Cancer Potential on Highly and Weakly Metastatic Human Breast Cancer Cells" Proceedings 105, no. 1: 24. https://doi.org/10.3390/proceedings2024105024

APA Style

Umar, H., & Aliyu, M. R. (2024). Moringa arborea-Mediated Iron Oxide Nanoparticles, Their Characterization and Their Anti-Cancer Potential on Highly and Weakly Metastatic Human Breast Cancer Cells. Proceedings, 105(1), 24. https://doi.org/10.3390/proceedings2024105024

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