Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients
Abstract
1. Introduction
2. Relevant Section
3. Discussion
4. Conclusions and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gender | Age (Years) | Pre-Existing Neurological Disease | Respiratory/Neurological Symptoms Due to COVID-19 | Neurological Symptoms at Arrival to the Hospital | Presence of SARS-CoV-2 Nasopharyngeal/CSF | Deregulated Biochemical Parameters | Immunological Parameters | Cytokine Profile in CSF | ||
---|---|---|---|---|---|---|---|---|---|---|
Case 1 | Female | 54 | CVD (acute intra-axial hemorrhage) | Without symptoms | -Moderate headache -Balance impairment -Weakness -Loss of consciousness | Positive/Negative | Dimer-D (14,760 Ug/L) Glucose (161 mg/dL) Total cholesterol (236 mg/dL) | Leukocytosis (12.10 × 103/mm3) Lymphopenia (0.70 × 103/ mm3) Neutrophilia (11.30 × 103/ mm3) Monocytopenia (0.1 × 103/ mm3) | IL-8 MCP-1 IFN-α | |
Case 2 | Male | 45 | CVD (diffuse subarachnoid hemorrhage) | Without symptoms | -Seizure -Psychomotor agitation -Disorientation | Positive/Negative | Dimer-D (4304 Ug/L) Fibrinogen (562 mg/dL) | Leukocytosis (15.70 × 103/ mm3) Lymphopenia (0.90 × 103/ mm3) Neutrophilia (14.20 × 103/ mm3) | IL-8 MCP-1 IFN-α | |
Case 3 | Female | 43 | Brain tumor (petroclival meningioma) | Pneumonia | -Severe headache -Drowsiness | Positive/Positive | Triglycerides (372 mg/dL) Glucose (110 mg/dL) ALT (70 U/L) Q-albumin (7.3 × 10−3 g/dL) | Leukocytosis (12.40 × 103/ mm3) Neutrophilia (9.10 × 103/ mm3) Monocytopenia (0.2 × 103/ mm3) | IL-12 IL-2 IL-13 | |
Case 4 | Male | 43 | Brain tumor (in the fourth ventricle) | Anosmia Peripheral oxygen saturation of 89% Neurological impairment Pneumonia | -Intense headache -Syncope -Gait abnormalities -Decreased alertness | Positive/Negative | ALT (79 U/L) | Leukocytosis (12.40 × 103/ mm3) Neutrophilia (14.20 × 103/ mm3) Lymphopenia (0.90 × 103/ mm3) Monocytopenia (0.1 × 103/ mm3) | IL-12 IL-2 IL-13 |
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Méndez-García, L.A.; Solleiro-Villavicencio, H.; Guartazaca-Guerrero, S.; Rodríguez-Morales, J.; Carrillo-Ruiz, J.D. Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients. Trop. Med. Infect. Dis. 2023, 8, 290. https://doi.org/10.3390/tropicalmed8060290
Méndez-García LA, Solleiro-Villavicencio H, Guartazaca-Guerrero S, Rodríguez-Morales J, Carrillo-Ruiz JD. Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients. Tropical Medicine and Infectious Disease. 2023; 8(6):290. https://doi.org/10.3390/tropicalmed8060290
Chicago/Turabian StyleMéndez-García, Lucía Angélica, Helena Solleiro-Villavicencio, Sebastián Guartazaca-Guerrero, Jahir Rodríguez-Morales, and José Damián Carrillo-Ruiz. 2023. "Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients" Tropical Medicine and Infectious Disease 8, no. 6: 290. https://doi.org/10.3390/tropicalmed8060290
APA StyleMéndez-García, L. A., Solleiro-Villavicencio, H., Guartazaca-Guerrero, S., Rodríguez-Morales, J., & Carrillo-Ruiz, J. D. (2023). Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients. Tropical Medicine and Infectious Disease, 8(6), 290. https://doi.org/10.3390/tropicalmed8060290