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Tomography, Volume 11, Issue 9
September 2025 - 12 articles
Cover Story: Several sequences for magnetization transfer contrast (MTC) imaging are available, ranging from quantitative magnetization transfer (qMT) that yields the macromolecular fraction to simple ratios of signal intensities with and without a magnetization transfer (MT) pulse. Aging muscle undergoes changes including an increase in fibrosis and fiber atrophy; the objective is to evaluate five MTC sequences to study age-related differences in muscle tissue composition. Significant age-related decreases in macromolecular fraction, MTsat, MTR, and MTRcorr were identified. Age-related decreases in MTC may reflect that loss of myofibrillar proteins dominates the increase in collagen with age. The MTsat sequence was identified as clinically relevant in terms of scan time and sensitivity to age-related differences in macromolecular fraction. View this paper
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Tomography - ISSN 2379-139X