AI-Radiomics Can Improve Inclusion Criteria and Clinical Trial Performance
Round 1
Reviewer 1 Report
I wish to commend the Authors for this interesting and well-written article. In particular, the radiomics application proposed is novel and supported by a robust pipeline.
I only have some minor comments:
1) In the final paragraphs of the Discussion, the Authors briefly mention two very relevant issues (could SRE be the key radiomic feature for selective patient inclusion in different maligancies and drugs too? Could this be performed before a trial begins?). While I feel that the present study does not allow to make strong claims one way or the other, I believe that the Authors should try to wider discuss this points, to offer a more comprehensive view to the readership and guide future research.
2) Please, check the manuscript for typos (e.g. page 2 line 75 "thee")
3) There is an inconsistency between the number of included patients as reported in the abstract and table 1 (296) and on page 3 lines 97-98 (294). Please, check and clarify.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Reviewer 2 Report
Perhaps it is worth changing the arrangement of fragments of Figures 1 - 3 in order to increase their geometric dimensions and improve the quality of images. In the proposed version, the images are fuzzy.
Author Response
Please see the attachment
Author Response File: Author Response.pdf