Next Article in Journal
Fluorescence Lifetime Imaging of Apoptosis
Previous Article in Journal
Potential for Early Fracture Risk Assessment in Patients with Metastatic Bone Disease Using Parametric Response Mapping of CT Images
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Tomography
Volume 1
Issue 2
10.18383/j.tom.2015.00175
tomography-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients

by
Xiang Xu
1,5,
Nirbhay N. Yadav
1,5,
Linda Knutsson
7,
Jun Hua
1,5,
Rita Kalyani
2,
Erica Hall
2,
John Laterra
3,6,
Jaishri Blakeley
3,6,
Roy Strowd
3,6,
Martin Pomper
1,
Peter Barker
1,5,
Kannie W. Y. Chan
1,5,
Guanshu Liu
1,5,
Michael T. McMahon
1,5,
Robert D. Stevens
1,3,4,5 and
Peter C. M. van Zijl
1,5,8,*
1
Russell H. Morgan Department of Radiology and Radiological Science
2
Division of Endocrinology, Diabetes and Metabolism
3
Departments of Neurology, Oncology, and Neuroscience
4
Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
5
F.M. Kirby Research Center for Functional Brain Imaging
6
Hugo W. Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD, USA
7
Department of Medical Radiation Physics, Lund University, Lund, Sweden
8
F.M. Kirby Research Center, Kennedy Krieger Research Institute, 707 N. Broadway, Baltimore, MD 21205, USA
*
Author to whom correspondence should be addressed.
Tomography 2015, 1(2), 105-114; https://doi.org/10.18383/j.tom.2015.00175
Submission received: 4 September 2015 / Revised: 5 October 2015 / Accepted: 6 November 2015 / Published: 1 December 2015
Versions Notes

Abstract

Recent animal studies have shown that D-glucose is a potential biodegradable magnetic resonance imaging (MRI) contrast agent for imaging glucose uptake in tumors. We show herein the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detecting hydroxyl protons in D-glucose was used to image dynamic signal changes in the human brain at 7 T during and after D-glucose infusion. Dynamic glucose enhanced (DGE) image data from 4 normal volunteers and 3 glioma patients showed a strong signal enhancement in blood vessels, while a spatially varying enhancement was found in tumors. Areas of enhancement differed spatially between DGE and conventional gadolinium-enhanced imaging, suggesting complementary image information content for these 2 types of agents. In addition, different tumor areas enhanced with D-glucose at different times after infusion, suggesting a sensitivity to perfusion-related properties such as substrate delivery and blood-brain barrier (BBB) permeability. These preliminary results suggest that DGE MRI is feasible for studying glucose uptake in humans, providing a time-dependent set of data that contains information regarding arterial input function, tissue perfusion, glucose transport across the BBB and cell membrane, and glucose metabolism.
Keywords: d-glucose; perfusion; chemical exchange saturation transfer; CEST; dynamic glucose-enhanced MRI; glioma patients d-glucose; perfusion; chemical exchange saturation transfer; CEST; dynamic glucose-enhanced MRI; glioma patients

Share and Cite

MDPI and ACS Style

Xu, X.; Yadav, N.N.; Knutsson, L.; Hua, J.; Kalyani, R.; Hall, E.; Laterra, J.; Blakeley, J.; Strowd, R.; Pomper, M.; et al. Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients. Tomography 2015, 1, 105-114. https://doi.org/10.18383/j.tom.2015.00175

AMA Style

Xu X, Yadav NN, Knutsson L, Hua J, Kalyani R, Hall E, Laterra J, Blakeley J, Strowd R, Pomper M, et al. Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients. Tomography. 2015; 1(2):105-114. https://doi.org/10.18383/j.tom.2015.00175

Chicago/Turabian Style

Xu, Xiang, Nirbhay N. Yadav, Linda Knutsson, Jun Hua, Rita Kalyani, Erica Hall, John Laterra, Jaishri Blakeley, Roy Strowd, Martin Pomper, and et al. 2015. "Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients" Tomography 1, no. 2: 105-114. https://doi.org/10.18383/j.tom.2015.00175

APA Style

Xu, X., Yadav, N. N., Knutsson, L., Hua, J., Kalyani, R., Hall, E., Laterra, J., Blakeley, J., Strowd, R., Pomper, M., Barker, P., Chan, K. W. Y., Liu, G., McMahon, M. T., Stevens, R. D., & van Zijl, P. C. M. (2015). Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients. Tomography, 1(2), 105-114. https://doi.org/10.18383/j.tom.2015.00175

Article Metrics

Back to TopTop