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Article

Nitrogen-Doped Arginine Carbon Dots and Its Metal Nanoparticle Composites as Antibacterial Agent

1
Department of Chemistry, Faculty of Sciences & Arts, and Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University Terzioglu Campus, Canakkale 17100, Turkey
2
Department of Fashion Design, Faculty of Canakkale School of Applied Science, Canakkale Onsekiz Mart University Terzioglu Campus, Canakkale 17100, Turkey
3
Department of Ophalmology, College of Medicine, University of South Florida, Tampa, FL 33620, USA
4
Department of Chemical & Biomedical Engineering, and Materials Science and Engineering Program, University of South Florida, Tampa, FL 33620, USA
*
Author to whom correspondence should be addressed.
Received: 31 August 2020 / Revised: 12 September 2020 / Accepted: 17 September 2020 / Published: 21 September 2020
(This article belongs to the Special Issue Graphene and Carbon Quantum Dots, and Related 2D Quantum Dots)
Nitrogen (N)-doped arginine carbon dots (Arg CD) were successfully synthesized using arginine as the amine source and citric acid as the carbon source via a one-pot green synthesis microwave-assisted technique in 2 min. Ag and Cu nanoparticles (NP) were generated within N-doped Arg CDs as composite Arg-Ag CDs and Arg-Cu CDs to render enhanced antibacterial properties. TEM analysis revealed that Arg CDs are in graphitic structures with d spacing ranging from 0.5 nm to 10 nm. The minimum inhibition concentration (MIC) values of Arg CDs with 6.250 mg/mL were decreased by about 100-fold for Arg-Ag CDs and ten-fold for Arg-Cu CDs with 0.062 and 0.625 mg/mL MIC values against Staphylococcus aureus (S. aureus). The highest antibacterial susceptibility was observed for the Arg-Ag CD composite with 0.125 and 0.312 mg/mL minimum bactericidal concentration (MBC) values against Gram negative S. aureus and Gram positive Escherichia coli (E. coli) bacteria strains, respectively. It was found that the metal NPs within Arg CDs significantly increased the antibacterial properties of CDs making them available in the treatment of infections caused by different bacterial species. Furthermore, Arg-Ag CD and Arg-Cu CD composites were tested for Acetylcholinesterase (AChE, E.C. 3.1.1.7) that break down acetylcholine (ACh) into choline and acetic acid leading to the loss of ACh which plays an essential role as neurotransmitter in Alzheimer disease. It was found that Arg-Cu CDs inhibited 74.9 ± 0.8% and Arg-Ag CDs inhibited 52.1 ± 3.8% of AChE at a 1.82 mg/mL concentration versus no inhibition for Arg-CD. Moreover, the chelating activity of Arg-Cu CDs and Arg-Ag CDs were tested for Fe(II) and it was found that almost 100% chelating was attained at 116 μg composites versus no measurable chelation for bare Arg CDs, suggesting the potential neurodegenerative disease treatment properties of these composite CDs in the brain. View Full-Text
Keywords: Arginine; nitrogen-doped carbon dots (CD); microwave treatment; metal nanoparticle composite CD; antimicrobial/AChE inhibitor Arginine; nitrogen-doped carbon dots (CD); microwave treatment; metal nanoparticle composite CD; antimicrobial/AChE inhibitor
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MDPI and ACS Style

Suner, S.S.; Sahiner, M.; Ayyala, R.S.; Bhethanabotla, V.R.; Sahiner, N. Nitrogen-Doped Arginine Carbon Dots and Its Metal Nanoparticle Composites as Antibacterial Agent. C 2020, 6, 58. https://doi.org/10.3390/c6030058

AMA Style

Suner SS, Sahiner M, Ayyala RS, Bhethanabotla VR, Sahiner N. Nitrogen-Doped Arginine Carbon Dots and Its Metal Nanoparticle Composites as Antibacterial Agent. C. 2020; 6(3):58. https://doi.org/10.3390/c6030058

Chicago/Turabian Style

Suner, Selin S.; Sahiner, Mehtap; Ayyala, Ramesh S.; Bhethanabotla, Venkat R.; Sahiner, Nurettin. 2020. "Nitrogen-Doped Arginine Carbon Dots and Its Metal Nanoparticle Composites as Antibacterial Agent" C 6, no. 3: 58. https://doi.org/10.3390/c6030058

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