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Understanding Long Noncoding RNA and Chromatin Interactions: What We Know So Far

1
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, 40530 Gothenburg, Sweden
2
Department of Cell Biology, Memorial Sloan Kettering Cancer Centre, Rockefeller Research Laboratory, 430 East 67th Street, RRL 445, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2019, 5(4), 54; https://doi.org/10.3390/ncrna5040054
Received: 17 October 2019 / Revised: 25 November 2019 / Accepted: 29 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Non-Coding RNA and Intracellular Structures)
With the evolution of technologies that deal with global detection of RNAs to probing of lncRNA-chromatin interactions and lncRNA-chromatin structure regulation, we have been updated with a comprehensive repertoire of chromatin interacting lncRNAs, their genome-wide chromatin binding regions and mode of action. Evidence from these new technologies emphasize that chromatin targeting of lncRNAs is a prominent mechanism and that these chromatin targeted lncRNAs exert their functionality by fine tuning chromatin architecture resulting in an altered transcriptional readout. Currently, there are no unifying principles that define chromatin association of lncRNAs, however, evidence from a few chromatin-associated lncRNAs show presence of a short common sequence for chromatin targeting. In this article, we review how technological advancements contributed in characterizing chromatin associated lncRNAs, and discuss the potential mechanisms by which chromatin associated lncRNAs execute their functions. View Full-Text
Keywords: lncrna; chromatin; chromatin RNA; long noncoding RNA; gene regulation; RNA-chromatin interactions lncrna; chromatin; chromatin RNA; long noncoding RNA; gene regulation; RNA-chromatin interactions
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Mishra, K.; Kanduri, C. Understanding Long Noncoding RNA and Chromatin Interactions: What We Know So Far. Non-Coding RNA 2019, 5, 54.

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