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MiR-205 Dysregulations in Breast Cancer: The Complexity and Opportunities

Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA
Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China
Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA
Author to whom correspondence should be addressed.
Non-Coding RNA 2019, 5(4), 53;
Received: 16 October 2019 / Revised: 12 November 2019 / Accepted: 13 November 2019 / Published: 19 November 2019
(This article belongs to the Special Issue Non-Coding RNAs as Therapeutic Targets)
MicroRNAs (miRNAs) are endogenous non-coding small RNAs that downregulate target gene expression by imperfect base-pairing with the 3′ untranslated regions (3′UTRs) of target gene mRNAs. MiRNAs play important roles in regulating cancer cell proliferation, stemness maintenance, tumorigenesis, cancer metastasis, and cancer therapeutic resistance. While studies have shown that dysregulation of miRNA-205-5p (miR-205) expression is controversial in different types of human cancers, it is generally observed that miR-205-5p expression level is downregulated in breast cancer and that miR-205-5p exhibits a tumor suppressive function in breast cancer. This review focuses on the role of miR-205-5p dysregulation in different subtypes of breast cancer, with discussions on the effects of miR-205-5p on breast cancer cell proliferation, epithelial–mesenchymal transition (EMT), metastasis, stemness and therapy-resistance, as well as genetic and epigenetic mechanisms that regulate miR-205-5p expression in breast cancer. In addition, the potential diagnostic and therapeutic value of miR-205-5p in breast cancer is also discussed. A comprehensive list of validated miR-205-5p direct targets is presented. It is concluded that miR-205-5p is an important tumor suppressive miRNA capable of inhibiting the growth and metastasis of human breast cancer, especially triple negative breast cancer. MiR-205-5p might be both a potential diagnostic biomarker and a therapeutic target for metastatic breast cancer. View Full-Text
Keywords: miR-205-5p (miR-205); breast cancer; metastatic breast cancer; triple negative breast cancer; luminal A/B breast cancer; Her2+ breast cancer miR-205-5p (miR-205); breast cancer; metastatic breast cancer; triple negative breast cancer; luminal A/B breast cancer; Her2+ breast cancer
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Xiao, Y.; Humphries, B.; Yang, C.; Wang, Z. MiR-205 Dysregulations in Breast Cancer: The Complexity and Opportunities. Non-Coding RNA 2019, 5, 53.

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