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Gels, Volume 6, Issue 4

2020 December - 19 articles

Cover Story: Graphene oxide (GO)-reinforced oleogels of cocoa butter (CB; oleogelator) and rice bran oil (RBO; liquid phase) were developed as ophthalmic drug delivery systems. The inclusion of GO within the CB-RBO oleogel considerably altered the microstructure of the prepared oleogels. GO-loaded oleogels showed significant enhancements in the crystalline nature, elasticity, and stress-bearing properties. Moreover, the crystallization process of CB in the oleogels was delayed in the presence of GO. Both X-ray diffraction and thermal studies confirmed the crystallization of CB in stable β’ and β polymorphic forms in each of the oleogels. It was observed that the inclusion of GO within the oleogels could increase the ex-vivo corneal permeation of the model drug (ciprofloxacin HCl) across the corneal tissue. View this paper
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Articles (19)

  • Article
  • Open Access
16 Citations
5,028 Views
13 Pages

15 December 2020

The incorporation of cyclodextrins into polymeric crosslinked gels of hydrophilic nature can be useful for promoting the sorption of hydrophobic molecules and/or modulating the release of active principles. The covalent addition of these excipients t...

  • Article
  • Open Access
3 Citations
4,715 Views
16 Pages

14 December 2020

Wide-pore proteinaceous freeze–thaw spongy gels were synthesized via the cryotropic gelation technique using the bovine blood serum or its diluted solutions as the protein-containing precursors. The feed systems also included the denaturant (ur...

  • Article
  • Open Access
92 Citations
7,994 Views
11 Pages

Nanoporous Sodium Carboxymethyl Cellulose-g-poly (Sodium Acrylate)/FeCl3 Hydrogel Beads: Synthesis and Characterization

  • Bijender Kumar,
  • Ruchir Priyadarshi,
  • Sauraj,
  • Farha Deeba,
  • Anurag Kulshreshtha,
  • Kirtiraj K. Gaikwad,
  • Jaehwan Kim,
  • Anuj Kumar and
  • Yuvraj Singh Negi

11 December 2020

Novel sodium carboxymethyl cellulose-g-poly (sodium acrylate)/Ferric chloride (CMC-g-PNaA/FeCl3) nanoporous hydrogel beads were prepared based on the ionic cross-linking between CMC-g-PNaA and FeCl3. The structure of CMC and CMC-g-PNaA were elucidate...

  • Review
  • Open Access
19 Citations
4,231 Views
18 Pages

Creating Structured Hydrogel Microenvironments for Regulating Stem Cell Differentiation

  • David K. Mills,
  • Yangyang Luo,
  • Anusha Elumalai,
  • Savannah Esteve,
  • Sonali Karnik and
  • Shaomian Yao

2 December 2020

The development of distinct biomimetic microenvironments for regulating stem cell behavior and bioengineering human tissues and disease models requires a solid understanding of cell–substrate interactions, adhesion, and its role in directing ce...

  • Communication
  • Open Access
41 Citations
9,001 Views
11 Pages

27 November 2020

Collagen-based hydrogels are investigated extensively in tissue engineering for their tunable physiochemical properties, biocompatibility and biodegradability. However, the effect of the integrity of the collagen triple helical structure on biodegrad...

  • Article
  • Open Access
10 Citations
3,748 Views
12 Pages

25 November 2020

The most difficult issue when using tissue engineering products is enabling the ability to store them without losing their restorative capacity. The numbers and viability of mesenchymal stem cells encapsulated in a hydrogel scaffold after cryostorage...

  • Article
  • Open Access
3 Citations
3,479 Views
26 Pages

25 November 2020

Different numerical solutions of a previously developed mass transport model for supercritical drying of aerogel particles in a packed bed [Part 1: Selmer et al. 2018, Part 2: Selmer et al. 2019] are compared. Two finite difference discretizations an...

  • Article
  • Open Access
8 Citations
4,726 Views
14 Pages

23 November 2020

One-pot free-radical polymerization of N-acryloyl glycinamide in the presence of hyaluronic acid as transfer-termination agent led to new copolymers in high yields without any chemical activation of hyaluronic acid before. All the copolymers formed t...

  • Article
  • Open Access
15 Citations
5,065 Views
26 Pages

Graphene Oxide Increases Corneal Permeation of Ciprofloxacin Hydrochloride from Oleogels: A Study with Cocoa Butter-Based Oleogels

  • Dilshad Qureshi,
  • Barbiee Choudhary,
  • Biswaranjan Mohanty,
  • Preetam Sarkar,
  • Arfat Anis,
  • Miguel A. Cerqueira,
  • Indranil Banerjee,
  • Samarendra Maji and
  • Kunal Pal

23 November 2020

In this work, oleogels of cocoa butter (CB), rice bran oil (RBO), and graphene oxide (GO) were prepared. The prepared oleogels were subjected to various characterization techniques such as bright-field microscopy, X-ray diffraction (XRD), crystalliza...

  • Article
  • Open Access
12 Citations
4,411 Views
17 Pages

Role of N–Oxide Moieties in Tuning Supramolecular Gel-State Properties

  • Dipankar Ghosh,
  • Ragnar Bjornsson and
  • Krishna K. Damodaran

20 November 2020

The role of specific interactions in the self-assembly process of low molecular weight gelators (LMWGs) was studied by altering the nonbonding interactions responsible for gel formation via structural modification of the gelator/nongelator. This was...

  • Article
  • Open Access
2 Citations
2,847 Views
18 Pages

16 November 2020

We present a mean field theory to describe cholesteric elastomers and gels under an external field, such as an electric or a magnetic field, along the helix axis of a cholesteric phase. We study the deformations and volume phase transitions of choles...

  • Article
  • Open Access
46 Citations
8,429 Views
11 Pages

Polydopamine Antioxidant Hydrogels for Wound Healing Applications

  • Naphtali A. O’Connor,
  • Abdulhaq Syed,
  • Madeline Wong,
  • Josiah Hicks,
  • Greisly Nunez,
  • Andrei Jitianu,
  • Zach Siler and
  • Marnie Peterson

31 October 2020

Antioxidants are known to improve the wound healing process and are researched as a therapeutic strategy to treat chronic wounds. Dopamine is a known neurotransmitter with antioxidant properties that can be polymerized to form polydopamine (PDA). Her...

  • Article
  • Open Access
10 Citations
5,785 Views
10 Pages

28 October 2020

Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hyd...

  • Article
  • Open Access
12 Citations
4,110 Views
9 Pages

Characterization of Zinc Oxide Nanoparticle Cross-Linked Collagen Hydrogels

  • Yosra Agban,
  • Odunayo O. Mugisho,
  • Sachin S. Thakur and
  • Ilva D. Rupenthal

22 October 2020

Collagen is the most abundant protein in mammals and possesses high biocompatibility and low antigenicity. These biological properties render it one of the most useful biomaterials for medical applications. This study investigated the mechanical and...

  • Review
  • Open Access
47 Citations
12,245 Views
21 Pages

20 October 2020

Type I collagen and fibrin are two essential proteins in tissue regeneration and have been widely used for the design of biomaterials. While they both form hydrogels via fibrillogenesis, they have distinct biochemical features, structural properties...

  • Article
  • Open Access
5 Citations
3,565 Views
17 Pages

A Cellular Automata Approach for the Modeling of a Polyamide and Carbon Aerogel Structure and Its Properties

  • Natalia Menshutina,
  • Igor Lebedev,
  • Evgeniy Lebedev,
  • Patrina Paraskevopoulou,
  • Despoina Chriti and
  • Igor Mitrofanov

18 October 2020

In this work, a cellular automata (CA) approach was used to generate 3D structures of polyamide and carbon aerogels. Experimental results are used as initial data for materials’ digital representations and to verify the developed CA models. Bas...

  • Article
  • Open Access
10 Citations
3,935 Views
19 Pages

16 October 2020

Poly(N-isopropylacrylamide) (PNIPAM) hydrogel microparticles with different core–shell morphologies have been designed, while maintaining an unvaried chemical composition: a morphology with (i) an un-crosslinked core with a crosslinked shell of...

  • Article
  • Open Access
38 Citations
7,743 Views
17 Pages

Matrix Remodeling and Hyaluronan Production by Myofibroblasts and Cancer-Associated Fibroblasts in 3D Collagen Matrices

  • Jiranuwat Sapudom,
  • Claudia Damaris Müller,
  • Khiet-Tam Nguyen,
  • Steve Martin,
  • Ulf Anderegg and
  • Tilo Pompe

30 September 2020

The tumor microenvironment is a key modulator in cancer progression and has become a novel target in cancer therapy. An increase in hyaluronan (HA) accumulation and metabolism can be found in advancing tumor progression and are often associated with...

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Gels - ISSN 2310-2861