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Open AccessArticle

Tetraethyl Orthosilicate-Based Hydrogels for Drug Delivery—Effects of Their Nanoparticulate Structure on Release Properties

1
Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA
2
Department of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USA
3
Department of Chemistry and Biochemistry, University of Montana, Missoula, MT 59812, USA
*
Author to whom correspondence should be addressed.
Received: 1 August 2020 / Revised: 14 October 2020 / Accepted: 26 October 2020 / Published: 28 October 2020
(This article belongs to the Special Issue Hydrogels for Drug Delivery 2020)
Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications. View Full-Text
Keywords: tetraethyl orthosilicate; thixogel; nanoparticles; drug release tetraethyl orthosilicate; thixogel; nanoparticles; drug release
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MDPI and ACS Style

Serban, B.A.; Barrett-Catton, E.; Serban, M.A. Tetraethyl Orthosilicate-Based Hydrogels for Drug Delivery—Effects of Their Nanoparticulate Structure on Release Properties. Gels 2020, 6, 38.

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