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Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp.

1
Center of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
2
Medicinal Plants Innovation Center of Mae Fah Luang University, Chiang Rai 57100, Thailand
3
Center for Organic Electronic and Alternative Energy, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand
4
School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia
5
Center of Excellence in Fungal Research, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
6
School of Integrative Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand
*
Authors to whom correspondence should be addressed.
These authors have contributed equally to this work.
Academic Editor: Gary A. Strobel
J. Fungi 2021, 7(6), 408; https://doi.org/10.3390/jof7060408
Received: 9 May 2021 / Revised: 16 May 2021 / Accepted: 20 May 2021 / Published: 22 May 2021
(This article belongs to the Section Fungal Genomics, Genetics and Molecular Biology)
Chemical investigation of the mycelia of the pathogenic fungus Curvularia sp. which was isolated from a leaf of Dactyloctenium aegyptium (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circular dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activity with IC50 values of 53.7, 32.8, and 12.8 µM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC50 ranging value of 11.73 to 17.59 µM. View Full-Text
Keywords: Curvularia sp.; Dactyloctenium aegyptium; curvulariahawadride; cytotoxicity; nitric oxide production inhibitory activity Curvularia sp.; Dactyloctenium aegyptium; curvulariahawadride; cytotoxicity; nitric oxide production inhibitory activity
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MDPI and ACS Style

Suthiphasilp, V.; Raksat, A.; Maneerat, T.; Hadsadee, S.; Jungsuttiwong, S.; Pyne, S.G.; Chomnunti, P.; Jaidee, W.; Charoensup, R.; Laphookhieo, S. Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp. J. Fungi 2021, 7, 408. https://doi.org/10.3390/jof7060408

AMA Style

Suthiphasilp V, Raksat A, Maneerat T, Hadsadee S, Jungsuttiwong S, Pyne SG, Chomnunti P, Jaidee W, Charoensup R, Laphookhieo S. Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp. Journal of Fungi. 2021; 7(6):408. https://doi.org/10.3390/jof7060408

Chicago/Turabian Style

Suthiphasilp, Virayu, Achara Raksat, Tharakorn Maneerat, Sarinya Hadsadee, Siriporn Jungsuttiwong, Stephen G. Pyne, Putarak Chomnunti, Wuttichai Jaidee, Rawiwan Charoensup, and Surat Laphookhieo. 2021. "Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus Curvularia sp." Journal of Fungi 7, no. 6: 408. https://doi.org/10.3390/jof7060408

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