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Open AccessReview

Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance

by 1,2,†, 1,2,†, 3,4 and 1,2,*
1
VIB-KU Leuven Center for Microbiology, 3001 Leuven, Belgium
2
Laboratory of Molecular Cell Biology, Department of Biology, KU Leuven, 3001 Leuven, Belgium
3
Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3001 Leuven, Belgium
4
Department of Laboratory Medicine and National Reference Center for Mycosis, UZ Leuven, 3001 Leuven, Belgium
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Fungi 2020, 6(4), 321; https://doi.org/10.3390/jof6040321
Received: 30 October 2020 / Revised: 25 November 2020 / Accepted: 25 November 2020 / Published: 27 November 2020
Although polyenes were the first broad spectrum antifungal drugs on the market, after 70 years they are still the gold standard to treat a variety of fungal infections. Polyenes such as amphotericin B have a controversial image. They are the antifungal drug class with the broadest spectrum, resistance development is still relatively rare and fungicidal properties are extensive. Yet, they come with a significant host toxicity that limits their use. Relatively recently, the mode of action of polyenes has been revised, new mechanisms of drug resistance were discovered and emergent polyene resistant species such as Candida auris entered the picture. This review provides a short description of the history and clinical use of polyenes, and focusses on the ongoing debate concerning their mode of action, the diversity of resistance mechanisms discovered to date and the most recent trends in polyene resistance development. View Full-Text
Keywords: amphotericin B; polyene; antifungal drug resistance; mode of action; discovery amphotericin B; polyene; antifungal drug resistance; mode of action; discovery
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MDPI and ACS Style

Carolus, H.; Pierson, S.; Lagrou, K.; Van Dijck, P. Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance. J. Fungi 2020, 6, 321. https://doi.org/10.3390/jof6040321

AMA Style

Carolus H, Pierson S, Lagrou K, Van Dijck P. Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance. Journal of Fungi. 2020; 6(4):321. https://doi.org/10.3390/jof6040321

Chicago/Turabian Style

Carolus, Hans; Pierson, Siebe; Lagrou, Katrien; Van Dijck, Patrick. 2020. "Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance" J. Fungi 6, no. 4: 321. https://doi.org/10.3390/jof6040321

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