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National Public Health Response to Candida auris in England
Open AccessArticle

External Quality Assessment Evaluating the Ability of Dutch Clinical Microbiological Laboratories to Identify Candida auris

Department of Medical Microbiology, Radboud University Medical Center, 6525GA Nijmegen, The Netherlands
Center of Expertise in Mycology Radboudumc/CWZ, 6525GA Nijmegen, The Netherlands
Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), 6532SZ Nijmegen, The Netherlands
Author to whom correspondence should be addressed.
J. Fungi 2019, 5(4), 94;
Received: 30 August 2019 / Revised: 30 September 2019 / Accepted: 30 September 2019 / Published: 7 October 2019
(This article belongs to the Special Issue Candida auris)
Background: Candida auris is a yeast that is causing nosocomial outbreaks in healthcare facilities around the world. There is a risk of the misidentification of C. auris with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)—when libraries are used that lack C. auris spectra, or when conventional biochemical methods are used. Methods: We conducted an external quality assessment to evaluate the ability of Dutch clinical microbiological laboratories to identify C. auris, and to raise awareness about the risk of misidentification. Results: 35/47 participating laboratories were able to identify C. auris correctly. Only 2/14 labs that potentially misidentified C. auris with their primary identification methods specified that they would perform additional tests to exclude C. auris when appropriate. 45/47 labs used MALDI-TOF MS systems to identify Candida species. Conclusions: There was a lack of awareness about the potential misidentification of C. auris in many labs that used MALDI-TOF MS with libraries that lacked C. auris spectra, and labs that used Vitek 2. However, as the currently available MALDI-TOF MS libraries in The Netherlands contain several C. auris spectra, we expect that currently almost all participating laboratories are able to identify C. auris correctly, as 45/47 participating laboratories use MALDI-TOF MS as their primary yeast identification method. View Full-Text
Keywords: C. auris; MALDI-TOF MS; misidentification C. auris; MALDI-TOF MS; misidentification
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Buil, J.B.; van der Lee, H.A.L.; Curfs-Breuker, I.; Verweij, P.E.; Meis, J.F. External Quality Assessment Evaluating the Ability of Dutch Clinical Microbiological Laboratories to Identify Candida auris. J. Fungi 2019, 5, 94.

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