Triazole Resistance in Aspergillus spp.: A Worldwide Problem?
AbstractSince the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance. Firstly reported in the USA and soon after in Europe, it has now been described worldwide, challenging the management of human aspergillosis. The main mechanism of resistance is the modification of the azole target enzyme: 14-α sterol demethylase, encoded by the cyp51A gene; although recently, other resistance mechanisms have also been implicated. In addition, a shift in the epidemiology has been noted with other Aspergillus species (mostly azole resistant) increasingly being reported as causative agents of human disease. This paper reviews the current situation of Aspergillus azole resistance and its implications in the clinical setting. View Full-Text
Share & Cite This Article
Rivero-Menendez, O.; Alastruey-Izquierdo, A.; Mellado, E.; Cuenca-Estrella, M. Triazole Resistance in Aspergillus spp.: A Worldwide Problem? J. Fungi 2016, 2, 21.
Rivero-Menendez O, Alastruey-Izquierdo A, Mellado E, Cuenca-Estrella M. Triazole Resistance in Aspergillus spp.: A Worldwide Problem? Journal of Fungi. 2016; 2(3):21.Chicago/Turabian Style
Rivero-Menendez, Olga; Alastruey-Izquierdo, Ana; Mellado, Emilia; Cuenca-Estrella, Manuel. 2016. "Triazole Resistance in Aspergillus spp.: A Worldwide Problem?" J. Fungi 2, no. 3: 21.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.