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Function of Adenylyl Cyclase in Heart: the AKAP Connection

Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2018, 5(1), 2;
Received: 19 December 2017 / Revised: 9 January 2018 / Accepted: 11 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Cyclic Nucleotide Signaling and the Cardiovascular System)
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways. Local pools of cAMP are maintained by macromolecular complexes formed by A-kinase anchoring proteins (AKAPs). AKAPs facilitate control by bringing together regulators of the cAMP pathway including G-protein-coupled receptors, ACs, and downstream effectors of cAMP to finely tune signaling. This review will summarize the distinct roles of AC isoforms in cardiac function and how interactions with AKAPs facilitate AC function, highlighting newly appreciated roles for lesser abundant AC isoforms. View Full-Text
Keywords: adenylyl cyclase; A-kinase anchoring proteins; cyclic AMP; cardiomyocytes adenylyl cyclase; A-kinase anchoring proteins; cyclic AMP; cardiomyocytes
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Baldwin, T.A.; Dessauer, C.W. Function of Adenylyl Cyclase in Heart: the AKAP Connection. J. Cardiovasc. Dev. Dis. 2018, 5, 2.

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