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Volume 8
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Article

The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route

by
Ekaterina Nefedova
1,
Vyacheslav Koptev
1,
Anna S. Bobikova
1,2,
Viktoria Cherepushkina
1,
Tatyana Mironova
1,2,
Vasily Afonyushkin
1,3,
Nikolai Shkil
1,
Nikolai Donchenko
1,
Yulia Kozlova
3,
Natalia Sigareva
2,
Natalia Davidova
1,
Nina Bogdanchikova
4,*,
Alexey Pestryakov
5 and
Yanis Toledano-Magaña
6,*
1
Siberian Federal Scientific Center of Agro-BioTechnologies of Russian Academy of Sciences, Novosibirsk Region, Novosibirsk District, 630501 Krasnoobsk, Russia
2
Molecular Biology Department, Federal State Budgetary Educational Institution Higher Education Novosibirsk State Agrarian University, 630090 Novosibirsk, Russia
3
Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia
4
Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Ensenada 22860, BC, Mexico
5
Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia
6
Escuela de Ciencias de la Salud Unidad Valle Dorado, Universidad Autónoma de Baja California, Ensenada 22890, BC, Mexico
*
Authors to whom correspondence should be addressed.
Vet. Sci. 2021, 8(10), 239; https://doi.org/10.3390/vetsci8100239
Submission received: 7 September 2021 / Revised: 10 October 2021 / Accepted: 12 October 2021 / Published: 18 October 2021
(This article belongs to the Special Issue Addressing New Therapeutic Strategies Using Models)
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Abstract

Infectious bronchitis (IB) of chickens is a highly contagious disease characterized by damage of the respiratory system and reproductive organs in young animals caused by a virus of the genus Gamma coronavirus. The condition of the respiratory system caused by the IB virus in chickens has many similarities with the pathology of the respiratory system caused by SARS-CoV-2 in humans. The effectiveness of virucidal drugs (Argovit, Triviron, Ecocid, and lauric acid monoglyceride) was tested on chickens inoculated with a tenfold dose of a vaccine strain based on the attenuated virus H120 against IB of chickens. On the 6th day after inoculation, inflammatory changes in the intestines, lungs, and thymus were observed in the control group. The experimental groups were characterized by less pronounced inflammatory reactions and a lower proportion of thymus and lung probes containing genomic IB virus RNA. Since the virucidal activity of four orally administrated formulations was possible only in the intestine, the experimental data indirectly confirmed the hypothesis of the possibility of the predominant accumulation of coronaviruses in the intestine and subsequent lung damage due to the hematogenous redistribution of viral particles and IBV antigens. It was suggested that other coronaviruses including SARS-CoV-2 can implement a similar mechanism.
Keywords: virucidal drugs; IBV; chickens; Coronaviridae; silver nanoparticles; artificial ribonuclease; monoglyceride lauryl acid virucidal drugs; IBV; chickens; Coronaviridae; silver nanoparticles; artificial ribonuclease; monoglyceride lauryl acid

Share and Cite

MDPI and ACS Style

Nefedova, E.; Koptev, V.; Bobikova, A.S.; Cherepushkina, V.; Mironova, T.; Afonyushkin, V.; Shkil, N.; Donchenko, N.; Kozlova, Y.; Sigareva, N.; et al. The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route. Vet. Sci. 2021, 8, 239. https://doi.org/10.3390/vetsci8100239

AMA Style

Nefedova E, Koptev V, Bobikova AS, Cherepushkina V, Mironova T, Afonyushkin V, Shkil N, Donchenko N, Kozlova Y, Sigareva N, et al. The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route. Veterinary Sciences. 2021; 8(10):239. https://doi.org/10.3390/vetsci8100239

Chicago/Turabian Style

Nefedova, Ekaterina, Vyacheslav Koptev, Anna S. Bobikova, Viktoria Cherepushkina, Tatyana Mironova, Vasily Afonyushkin, Nikolai Shkil, Nikolai Donchenko, Yulia Kozlova, Natalia Sigareva, and et al. 2021. "The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route" Veterinary Sciences 8, no. 10: 239. https://doi.org/10.3390/vetsci8100239

APA Style

Nefedova, E., Koptev, V., Bobikova, A. S., Cherepushkina, V., Mironova, T., Afonyushkin, V., Shkil, N., Donchenko, N., Kozlova, Y., Sigareva, N., Davidova, N., Bogdanchikova, N., Pestryakov, A., & Toledano-Magaña, Y. (2021). The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route. Veterinary Sciences, 8(10), 239. https://doi.org/10.3390/vetsci8100239

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