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Article

A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue

1
Food Application and Development Laboratory, Advanced Enzymes Technologies Ltd., Louiswadi, Thane 400604, India
2
Pulmonary Fibrosis Now, Chino, CA 91710, USA
*
Author to whom correspondence should be addressed.
Academic Editor: William Cho
Medicines 2021, 8(9), 47; https://doi.org/10.3390/medicines8090047
Received: 16 August 2021 / Revised: 25 August 2021 / Accepted: 26 August 2021 / Published: 30 August 2021
Muscle fatigue and cognitive disturbances persist in patients after recovery from acute COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) in patients suffering from COVID-19 induced fatigue. A randomized, multicentric, double blind, placebo-controlled trial was conducted in 200 patients with a complaint of post-COVID fatigue. The test arm (n = 100) received the oral supplements for 14 days and the control arm (n = 100) received a placebo. Treatment efficacy was compared using the Chalder Fatigue scale (CFQ-11), at various time points from days 1 to 14. The supplemental treatment resulted in resolution of fatigue in a greater percentage of subjects in the test vs. the control arm (91% vs. 15%) on day 14. Subjects in the test arm showed a significantly greater reduction in total as well as physical and mental fatigue scores at all time points vs. the control arm. The supplements were well tolerated with no adverse events reported. This study demonstrates that a 14 days supplementation of ImmunoSEB + ProbioSEB CSC3 resolves post-COVID-19 fatigue and can improve patients’ functional status and quality of life. View Full-Text
Keywords: SARS-CoV-2 infection; COVID-19-induced fatigue; chalder fatigue scale; physical fatigue; mental fatigue; ImmunoSEB + ProbioSEB CSC3 SARS-CoV-2 infection; COVID-19-induced fatigue; chalder fatigue scale; physical fatigue; mental fatigue; ImmunoSEB + ProbioSEB CSC3
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MDPI and ACS Style

Rathi, A.; Jadhav, S.B.; Shah, N. A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue. Medicines 2021, 8, 47. https://doi.org/10.3390/medicines8090047

AMA Style

Rathi A, Jadhav SB, Shah N. A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue. Medicines. 2021; 8(9):47. https://doi.org/10.3390/medicines8090047

Chicago/Turabian Style

Rathi, Abhijit, Swati B. Jadhav, and Neha Shah. 2021. "A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue" Medicines 8, no. 9: 47. https://doi.org/10.3390/medicines8090047

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