Next Article in Journal
Nanotoxicology and Metalloestrogens: Possible Involvement in Breast Cancer
Next Article in Special Issue
Atrazine Exposure and Reproductive Dysfunction through the Hypothalamus-Pituitary-Gonadal (HPG) Axis
Previous Article in Journal
Current State of Developmental Neurotoxicology Research
Article

Hepatotoxicity, Nephrotoxicity and Oxidative Stress in Rat Testis Following Exposure to Haloxyfop-p-methyl Ester, an Aryloxyphenoxypropionate Herbicide

Biochemistry Unit, Department of Chemical Sciences, Ajayi Crowther University, PMB 1066, Oyo, Oyo State 211213, Nigeria
*
Author to whom correspondence should be addressed.
Academic Editor: Christos A. Damalas
Toxics 2015, 3(4), 373-389; https://doi.org/10.3390/toxics3040373
Received: 10 August 2015 / Revised: 7 October 2015 / Accepted: 9 October 2015 / Published: 15 October 2015
(This article belongs to the Collection Risk Assessment of Pesticide Exposure)
Haloxyfop-p-methyl ester (HPME) ((R)-2-{4-[3-chloro-5-(trifluoromethyl)-2-pyridyloxy]phenoxy}propionic acid), is a selective aryloxyphenoxypropionate (AOPP) herbicide. It exerts phytotoxicity through inhibition of lipid metabolism and induction of oxidative stress in susceptible plants. This study investigated the toxicological potentials of HPME in rats. Twenty-four male Wistar rats (170–210 g) were randomized into four groups (I–IV). Group I (control) received 1 mL of distilled water, while animals in Groups II, III and IV received 6.75, 13.5 and 27 mg/kg body weight HPME, respectively, for 21 days. There was a significant (p < 0.05) increase in renal and hepatic function biomarkers (urea, creatinine, total bilirubin, ALP, ALT, AST) in the plasma of treated animals compared to control. Levels of testicular antioxidants, ascorbic acid and glutathione, and activities of glutathione-S-transferase, superoxide dismutase and catalase were reduced significantly after 21 days of HPME administration in a dose-dependent manner. The testicular malondialdehyde level increased significantly in the HPME-treated rats relative to the control. A significant decrease in testicular lactate dehydrogenase, acid phosphatase and γ-glutamyl transferase was also observed in HPME-treated animals. Testicular histology revealed severe interstitial edema and sections of seminiferous tubules with necrotic and eroded germinal epithelium in the HPME-treated rats. Overall, data from this study suggest that HPME altered hepatic and renal function and induced oxidative stress and morphological changes in the testis of rats. View Full-Text
Keywords: aryloxyphenoxypropionate; haloxyfop-p-methyl ester; hepatotoxicity; nephrotoxicity; oxidative stress; testicular function; rat aryloxyphenoxypropionate; haloxyfop-p-methyl ester; hepatotoxicity; nephrotoxicity; oxidative stress; testicular function; rat
Show Figures

Graphical abstract

MDPI and ACS Style

Olayinka, E.T.; Ore, A. Hepatotoxicity, Nephrotoxicity and Oxidative Stress in Rat Testis Following Exposure to Haloxyfop-p-methyl Ester, an Aryloxyphenoxypropionate Herbicide. Toxics 2015, 3, 373-389. https://doi.org/10.3390/toxics3040373

AMA Style

Olayinka ET, Ore A. Hepatotoxicity, Nephrotoxicity and Oxidative Stress in Rat Testis Following Exposure to Haloxyfop-p-methyl Ester, an Aryloxyphenoxypropionate Herbicide. Toxics. 2015; 3(4):373-389. https://doi.org/10.3390/toxics3040373

Chicago/Turabian Style

Olayinka, Ebenezer T., and Ayokanmi Ore. 2015. "Hepatotoxicity, Nephrotoxicity and Oxidative Stress in Rat Testis Following Exposure to Haloxyfop-p-methyl Ester, an Aryloxyphenoxypropionate Herbicide" Toxics 3, no. 4: 373-389. https://doi.org/10.3390/toxics3040373

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop