Functionalization of Porphyrins Using Metal-Catalyzed C–H Activation
Round 1
Reviewer 1 Report
The manuscript by Gubarev and coworkers reviewed a particularly interesting sub-field in C-H activation methodologies such as the C-H activation/functionalization of porphyrins scaffolds. The manuscript is in general well written and easy to read through. The logic of the whole text is adequately followed and interesting. There are just some minor english spell to check. Importantly, befor acceptance there are few minor revision to do as follows:
1) all the reported procedure are mostly developed over pionerinng examples of C-H activation, not on porphyrins (meaning that are previously used in other transformation and subsequently applied to porphyrins). The prototypal C-H activation and their authors must be cited through the whole manuscript for clarity, and credits
2) The Authors must try to render the scheme and figure more captivating maybe using colors or a better organization of the structures
3) to many substrates have been showed in the figures try to reduce it
4) A final comment on the overall sustainability of the approaches presented must be inserted in the final conclusion with criticism
Author Response
Dear Reviewer 1,
Thanks for analysis of our work. We corrected paper in accordance with comments. All corrections are highlighted in red. Point-by-point answers are listed below in attached file.
Author Response File: 
Author Response.docx
Reviewer 2 Report
The manuscript entitled “Functionalization of Porphyrins Using Metal-Catalyzed C-H Activation” reviews a merited “niche” of porphyrin chemistry. It is predominantly directed to synthetic issues related to the synthesis. Given this manuscript’s particularity, I consider it sufficiently well written for publication. I would just appreciate to find what the most promising synthetic features were, considering the many routes depicted and discussed. Best metal catalysts/ligands used, etc, if possible. Each set of porphyrins is “unique”, but can the authors extract any selective information? Other than that, the manuscript is good for publication and fun to read.
Minor. In some schemes it appears “reaction of the”. It is redundant. For instance, in scheme 9, “Diarylation of 5,15-triarylporphyrin”, is sufficient.
Polishing the English language is advised, particularly regarding number and tense grammar.
Author Response
Dear Reviewer 2,
Thanks for analysis of our work. We corrected paper in accordance with comments. All corrections are highlighted in red. Point-by-point answers are listed below in attached file.
Author Response File: Author Response.docx
Reviewer 3 Report
The paper was intended to be a review of porphyrin functionalization using metal-catalyzed C-H activation.
Although the C-H metal-catalytic functionalization of porphyrins is not a widely used method for porphyrin synthesis, this method is promising because it allows the synthesis of a wide range of porphyrins from a small number of available precursors.
The number of papers based on the C-H metal-catalytic functionalization of porphyrins as methods of porphyrin synthesis is quite small in the literature and this could be a new and interesting area of porphyrins, known as ideal compounds in many fields.
The authors scanned the literature, most of which was fairly recent in the field, but failed to differentiate the new compounds from traditional porphyrin compounds. The materials are mixed and in conclusion and the effects are mixed, hard for readers in the field. Perhaps a re-structuring of porphyrins according to their type of application would be useful.
In addition, the paper does not contain analytical investigations of the new synthesized structures, which could have been representative for the clarity and eloquence of the data presented (eg MRI; FTIR, UV-Vis, etc.).
I propose to the authors to include a subchapter based on the analysis of the investigations of these porphyrins, as purity and success of synthesis, and a subchapter on abbreviations.
Author Response
Dear Reviewer 2,
Thanks for analysis of our work. We corrected paper in accordance with comments. All corrections are highlighted in red. Point-by-point answers are listed below in attached file.
Author Response File: Author Response.docx
