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GERMS is published by MDPI from Volume 25 Issue 4 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with the former publisher Infection Science Forum S.R.L..
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Article

Birth Outcome in HIV Vertically Exposed Children in Two Romanian Centers

by
Ana Maria Tudor
1,*,
Mariana Mărdărescu
2,
Cristina Petre
2,
Ruxandra Neagu Drăghicenoiu
2,
Rodica Ungurianu
2,
Cătălin Tilișcan
3,
Dan Oțelea
4,
Simona Claudia Cambrea
5,
Doina Eugenia Tănase
6,
Ana Maria Schweitzer
7 and
Simona Ruță
8
1
Pediatric Department, National Institute for Infectious Diseases "Prof Dr Matei Balș”, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2
Pediatric Department, National Institute for Infectious Diseases "Prof Dr Matei Balș”, Bucharest, Romania
3
National Institute for Infectious Diseases "Prof Dr Matei Balș” Carol Davila, University of Medicine and Pharmacy, Bucharest, Romania
4
National Institute for Infectious Diseases "Prof Dr Matei Balș”, Bucharest, Romania
5
Pediatric Department, Infectious Diseases Hospital Constanța, Faculty of Medicine, Ovidius University of Constanța, Romania
6
Pediatric Department Infectious Diseases Hospital Constanța, Constanța, Romania
7
Baylor Black Sea Foundation, Constanța, Romania
8
Ștefan S. Nicolau Institute of Virology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
*
Author to whom correspondence should be addressed.
GERMS 2015, 5(4), 116-124; https://doi.org/10.11599/germs.2015.1079
Submission received: 4 August 2015 / Revised: 26 September 2015 / Accepted: 30 September 2015 / Published: 2 December 2015
Versions Notes

Abstract

Background: The Romanian HIV epidemic is characterized by a high prevalence among children born in the late ’80s, perinatally infected. The impact of long‐term treatment on their offspring is unknown. We evaluated the influence of prenatal care on the rate of premature birth among the HIV‐exposed children of heavily treated HIV‐infected mothers in two Romanian centers. Methods: We retrospectively analyzed data on all patients born by HIV‐infected mothers between 2006 and 2012 followed up in two main regional centers. We compared the rate of premature birth and the differences between the sites regarding children and maternal demographic characteristics and antiretroviral exposure in pregnant women. Results: A total of 358 children born to 315 women were enrolled between 2006‐2012, 262 children from the National Institute for Infectious Diseases “Prof. Dr. Matei Balş” Bucharest (NIID) and 96 children from the Clinical Infectious Diseases Hospital Constanţa (IDHC). Gender rate in newborns and mean age in mothers were similar. We recorded statistically significant differences between centers in the rate of HIV vertical transmission (16.8% vs. 6.2%, p = 0.002) and prematurity (25.2 vs. 14.6%, p = 0.023). The most used antiretroviral combination during pregnancy in IDHC was boosted lopinavir and fixed dose zidovudine‐lamivudine (66% of cases), while in NIID a greater diversity of antiretrovirals were used. Women from IDHC were more frequently treated during pregnancy (83.3% vs. 68.6%, p = 0.004). HCV coinfection and illegal drug use were associated with prematurity in the NIID cohort (p = 0.037, p = 0.024). Conclusion: We found a higher rate of premature birth and HIV infection in NIID. In IDHC we found a higher rate of low birth weight in children and a higher rate of heavily treated women. Prematurity was associated with hepatitis C infection and illegal drug use in the NIID cohort.
Keywords: HIV exposure; antiretroviral drugs; prematurity HIV exposure; antiretroviral drugs; prematurity

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MDPI and ACS Style

Tudor, A.M.; Mărdărescu, M.; Petre, C.; Drăghicenoiu, R.N.; Ungurianu, R.; Tilișcan, C.; Oțelea, D.; Cambrea, S.C.; Tănase, D.E.; Schweitzer, A.M.; et al. Birth Outcome in HIV Vertically Exposed Children in Two Romanian Centers. GERMS 2015, 5, 116-124. https://doi.org/10.11599/germs.2015.1079

AMA Style

Tudor AM, Mărdărescu M, Petre C, Drăghicenoiu RN, Ungurianu R, Tilișcan C, Oțelea D, Cambrea SC, Tănase DE, Schweitzer AM, et al. Birth Outcome in HIV Vertically Exposed Children in Two Romanian Centers. GERMS. 2015; 5(4):116-124. https://doi.org/10.11599/germs.2015.1079

Chicago/Turabian Style

Tudor, Ana Maria, Mariana Mărdărescu, Cristina Petre, Ruxandra Neagu Drăghicenoiu, Rodica Ungurianu, Cătălin Tilișcan, Dan Oțelea, Simona Claudia Cambrea, Doina Eugenia Tănase, Ana Maria Schweitzer, and et al. 2015. "Birth Outcome in HIV Vertically Exposed Children in Two Romanian Centers" GERMS 5, no. 4: 116-124. https://doi.org/10.11599/germs.2015.1079

APA Style

Tudor, A. M., Mărdărescu, M., Petre, C., Drăghicenoiu, R. N., Ungurianu, R., Tilișcan, C., Oțelea, D., Cambrea, S. C., Tănase, D. E., Schweitzer, A. M., & Ruță, S. (2015). Birth Outcome in HIV Vertically Exposed Children in Two Romanian Centers. GERMS, 5(4), 116-124. https://doi.org/10.11599/germs.2015.1079

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