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Open AccessFeature PaperReview

Practical Solutions for Specific Growth Rate Control Systems in Industrial Bioreactors

Department of Automation, Kaunas University of Technology, 51367 Kaunas, Lithuania
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Processes 2019, 7(10), 693; https://doi.org/10.3390/pr7100693
Received: 27 August 2019 / Revised: 23 September 2019 / Accepted: 30 September 2019 / Published: 2 October 2019
(This article belongs to the Special Issue Bioprocess Monitoring and Control)
This contribution discusses the main challenges related to successful application of automatic control systems used to control specific growth rate in industrial biotechnological processes. It is emphasized that, after the implementation of basic automatic control systems, primary attention shall be paid to the specific growth rate control systems because this process variable critically affects the physiological state of microbial cultures and the formation of the desired product. Therefore, control of the specific growth rate enables improvement of the quality and reproducibility of the biotechnological processes. The main requirements have been formulated that shall be met to successfully implement the specific growth rate control systems in industrial bioreactors. The relatively easy-to-implement schemes of specific growth rate control systems have been reviewed and discussed. The recommendations for selection of particular control systems for specific biotechnological processes have been provided. View Full-Text
Keywords: biotechnological processes; bioreactor control; specific growth rate control; batch-to-batch reproducibility biotechnological processes; bioreactor control; specific growth rate control; batch-to-batch reproducibility
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Galvanauskas, V.; Simutis, R.; Levišauskas, D.; Urniežius, R. Practical Solutions for Specific Growth Rate Control Systems in Industrial Bioreactors. Processes 2019, 7, 693.

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