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Differences in Anxiety Levels of Various Murine Models in Relation to the Gut Microbiota Composition

Department of Advanced Green Energy and Environment, Handong Global University, Pohang-si, Gyeongbuk 37554, Korea
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Author to whom correspondence should be addressed.
Biomedicines 2018, 6(4), 113; https://doi.org/10.3390/biomedicines6040113
Received: 13 October 2018 / Revised: 23 November 2018 / Accepted: 26 November 2018 / Published: 4 December 2018
(This article belongs to the Section Neurologic Diseases)
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Abstract

Psychobiotics are probiotic strains that confer mental health benefits to the host through the modulation of the gut microbial population. Mounting evidence shows that the gut microbiota play an important role in communication within the gut–brain axis. However, the relationship between the host genetics and the gut microbiota and their influence on anxiety are still not fully understood. Hence, in our research, we attempted to draw a connection between host genetics, microbiota composition, and anxiety by performing an elevated plus maze (EPM) test on four genetically different mice. Four different breeds of 5-week-old mice were used in this experiment: Balb/c, Orient C57BL/6N, Taconic C57BL/6N, and Taconic C57BL/6J. After 1 week of adaptation, their initial anxiety level was monitored using the EPM test via an EthoVision XT, a standardized software used for behavorial testing. Significant differences in the initial anxiety level and microbial composition were detected. Subsequently, the microbiota of each group was modulated by the administration of either a probiotic, fecal microbiota transplantation, or antibiotics. Changes were observed in host anxiety levels in correlation to the shift of the gut microbiota. Our results suggest that the microbiota, host genetics, and psychological symptoms are strongly related, yet the deeper mechanistic links need further exploration. View Full-Text
Keywords: gut microbiota; probiotics; modulation; anxiety; host genetics gut microbiota; probiotics; modulation; anxiety; host genetics
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Huang, E.; Kang, S.; Park, H.; Park, S.; Ji, Y.; Holzapfel, W.H. Differences in Anxiety Levels of Various Murine Models in Relation to the Gut Microbiota Composition. Biomedicines 2018, 6, 113.

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