Next Article in Journal
Adiponectin Signaling Pathways in Liver Diseases
Next Article in Special Issue
Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides
Previous Article in Journal
Mammary Stem Cells and Breast Cancer Stem Cells: Molecular Connections and Clinical Implications
Previous Article in Special Issue
RNA-Targeted Therapies and Amyotrophic Lateral Sclerosis
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Biomedicines 2018, 6(2), 51;

Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
Author to whom correspondence should be addressed.
Received: 27 March 2018 / Revised: 21 April 2018 / Accepted: 3 May 2018 / Published: 5 May 2018
(This article belongs to the Special Issue Antisense Therapy)
Full-Text   |   PDF [1048 KB, uploaded 24 May 2018]   |  


The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back by their low bioavailability and poor cellular uptake to target tissues upon systemic administration. One such strategy to improve upon delivery is the use of short cell-penetrating peptides (CPPs) that can be either directly attached to their cargo through covalent linkages or through the formation of noncovalent nanoparticle complexes that can facilitate cellular uptake. In this review, we will highlight recent proof-of-principle studies that have utilized both of these strategies to improve nucleic acid delivery and discuss the prospects for translation of this approach for clinical application. View Full-Text
Keywords: cell-penetrating peptides; antisense oligonucleotides; delivery cell-penetrating peptides; antisense oligonucleotides; delivery

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

McClorey, G.; Banerjee, S. Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics. Biomedicines 2018, 6, 51.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top