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Biomedicines 2018, 6(2), 51; https://doi.org/10.3390/biomedicines6020051

Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
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Received: 27 March 2018 / Revised: 21 April 2018 / Accepted: 3 May 2018 / Published: 5 May 2018
(This article belongs to the Special Issue Antisense Therapy)
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Abstract

The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back by their low bioavailability and poor cellular uptake to target tissues upon systemic administration. One such strategy to improve upon delivery is the use of short cell-penetrating peptides (CPPs) that can be either directly attached to their cargo through covalent linkages or through the formation of noncovalent nanoparticle complexes that can facilitate cellular uptake. In this review, we will highlight recent proof-of-principle studies that have utilized both of these strategies to improve nucleic acid delivery and discuss the prospects for translation of this approach for clinical application. View Full-Text
Keywords: cell-penetrating peptides; antisense oligonucleotides; delivery cell-penetrating peptides; antisense oligonucleotides; delivery
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McClorey, G.; Banerjee, S. Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics. Biomedicines 2018, 6, 51.

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