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The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease

Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Author to whom correspondence should be addressed.
Biomedicines 2017, 5(4), 61;
Received: 21 August 2017 / Revised: 20 September 2017 / Accepted: 9 October 2017 / Published: 17 October 2017
(This article belongs to the Special Issue Cell Therapy for the Treatment of GVHD)
Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality following allogeneic stem cell transplantation. Current therapies, including corticosteroids and calcineurin inhibitors, are only effective in roughly 50% of cases; therefore, new treatment strategies are under investigation. What was previously felt to be a T cell disease has more recently been shown to involve activation of both T and B cells, as well as a number of cytokines. With a better understanding of its pathophysiology have come more expansive preclinical and clinical trials, many focused on B cell signaling. This report briefly reviews our current understanding of cGVHD pathophysiology and reviews clinical and preclinical trials with B cell-targeted agents. View Full-Text
Keywords: chronic graft-versus-host disease; B cell; rituximab; ibrutinib chronic graft-versus-host disease; B cell; rituximab; ibrutinib
MDPI and ACS Style

Rhoades, R.; Gaballa, S. The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease. Biomedicines 2017, 5, 61.

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