Next Article in Journal
Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies
Next Article in Special Issue
The Role of Anti-Thymocyte Globulin or Alemtuzumab-Based Serotherapy in the Prophylaxis and Management of Graft-Versus-Host Disease
Previous Article in Journal / Special Issue
A Critical Appraisal of Extracorporeal Photopheresis as a Treatment Modality for Acute and Chronic Graft-Versus-Host Disease
Open AccessReview

The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease

Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
*
Author to whom correspondence should be addressed.
Biomedicines 2017, 5(4), 61; https://doi.org/10.3390/biomedicines5040061
Received: 21 August 2017 / Revised: 20 September 2017 / Accepted: 9 October 2017 / Published: 17 October 2017
(This article belongs to the Special Issue Cell Therapy for the Treatment of GVHD)
Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality following allogeneic stem cell transplantation. Current therapies, including corticosteroids and calcineurin inhibitors, are only effective in roughly 50% of cases; therefore, new treatment strategies are under investigation. What was previously felt to be a T cell disease has more recently been shown to involve activation of both T and B cells, as well as a number of cytokines. With a better understanding of its pathophysiology have come more expansive preclinical and clinical trials, many focused on B cell signaling. This report briefly reviews our current understanding of cGVHD pathophysiology and reviews clinical and preclinical trials with B cell-targeted agents. View Full-Text
Keywords: chronic graft-versus-host disease; B cell; rituximab; ibrutinib chronic graft-versus-host disease; B cell; rituximab; ibrutinib
MDPI and ACS Style

Rhoades, R.; Gaballa, S. The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease. Biomedicines 2017, 5, 61.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop