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Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies

Pharmaceutical Sciences Department, Université de Bordeaux, BioTis, INSERM Unité 1026, 146 Rue Léo Saignat, 33076 Bordeaux, France
Department for Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri- Kansas City, 650 E 25th St, Kansas City, MO 64108, USA
Author to whom correspondence should be addressed.
Biomedicines 2017, 5(4), 62;
Received: 15 September 2017 / Revised: 9 October 2017 / Accepted: 18 October 2017 / Published: 24 October 2017
(This article belongs to the Special Issue Bone Cells and Related Interactions)
Osteoporosis and sarcopenia are age-related musculoskeletal pathologies that often develop in parallel. Osteoporosis is characterized by a reduced bone mass and an increased fracture risk. Sarcopenia describes muscle wasting with an increasing risk of injuries due to falls. The medical treatment of both diseases costs billions in health care per year. With the impact on public health and economy, and considering the increasing life expectancy of populations, more efficient treatment regimens are sought. The biomechanical interaction between both tissues with muscle acting on bone is well established. Recently, both tissues were also determined as secretory endocrine organs affecting the function of one another. New exciting discoveries on this front are made each year, with novel signaling molecules being discovered and potential controversies being described. While this review does not claim completeness, it will summarize the current knowledge on both the biomechanical and the biochemical link between muscle and bone. The review will highlight the known secreted molecules by both tissues affecting the other and finish with an outlook on novel therapeutics that could emerge from these discoveries. View Full-Text
Keywords: muscle; bone; crosstalk; biomechanical; hormones; therapeutics muscle; bone; crosstalk; biomechanical; hormones; therapeutics
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Maurel, D.B.; Jähn, K.; Lara-Castillo, N. Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies. Biomedicines 2017, 5, 62.

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