Next Article in Journal
Stem Cell Banking for Regenerative and Personalized Medicine
Next Article in Special Issue
Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1
Previous Article in Journal
Design and Potential of Non-Integrating Lentiviral Vectors
Open AccessReview

Oncolytic Adenoviruses in Cancer Treatment

by Ramon Alemany 1,2
Catalan Institute of Oncology (ICO), Av. Gran Via s/n km 2,7, Hospitalet de Llobregat, Barcelona 08907, Spain
Biomedical Research Institute of Bellvitge (IDIBELL), 3a planta - Gran Via de l'Hospitalet, 199, Hospitalet de Llobregat, Barcelona 08907, Spain 
Biomedicines 2014, 2(1), 36-49;
Received: 15 January 2014 / Revised: 13 February 2014 / Accepted: 14 February 2014 / Published: 21 February 2014
(This article belongs to the Special Issue Gene Therapy Used in Cancer Treatment)
The therapeutic use of viruses against cancer has been revived during the last two decades. Oncolytic viruses replicate and spread inside tumors, amplifying their cytotoxicity and simultaneously reversing the tumor immune suppression. Among different viruses, recombinant adenoviruses designed to replicate selectively in tumor cells have been clinically tested by intratumoral or systemic administration. Limited efficacy has been associated to poor tumor targeting, intratumoral spread, and virocentric immune responses. A deeper understanding of these three barriers will be required to design more effective oncolytic adenoviruses that, alone or combined with chemotherapy or immunotherapy, may become tools for oncologists. View Full-Text
Keywords: oncolytic; adenovirus; virotherapy; cancer oncolytic; adenovirus; virotherapy; cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Alemany, R. Oncolytic Adenoviruses in Cancer Treatment. Biomedicines 2014, 2, 36-49.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop